By alkene metathesis

Treatment of the 1,2-oxazines 52 with carbon monoxide at 1000 psi in the presence of cobalt carbonyl brings about insertion of carbon monoxide to form the 1,3-oxazepines S3 <96TL2713>. A convenient route to P-lactams fused to oxepines is made available by alkene metathesis. Thus reaction of 4-acetoxyazetidin-2-one with ally alcohol in the presence of zinc acetate, followed by iV-allylation of the nitrogen affords the derivative 54 which cyclises by RCM to form the oxazepinone 55 <96CC2231>. The same communication describes a similar synthesis of 1,3-dioxepines. 

It is also possible to study the self-assembly of individual molecules as well as networks such as 15.3. The V shaped zinc(II) bis (porphyrin) shown in Figure 15.20a self assembles into decaporphyrin pentagonic and dodecaporphyrin hexagonic assemblies. The assemblies can be fixed by alkene metathesis using Grubbs catalyst. This process represents self-assembly followed by covalent modification as described in Section 10.3.2. The assemblies can be directly imaged by high resolution STM (HRSTM)... 

Osipov, S. N., Artyushin, O. I., Kolomiets, A. F., et al. (2001) Synthesis of racemic cyclic amino acids Synthesis of fluorine-containing cyclic a-amino acid and a-amino phosphonate derivatives by alkene metathesis. Fur. J. Org. Chem., 3891-3897. 

Carbamoyl complexes from metal carbonyls and amines 5.8.2.12.4 Carbanions reactions with alkene complexes 5.8.2.3,4 metal carbonyls 5.8.2.S.5 Carbene complexes by alkene metathesis 5.8.2.3.11 formation 5.8.2.8.5 Carbides alkali metal formation 5.10.2.1 bonding 5.10.2 formation 5.10.2 industrial uses 5.10.2 interstitial formation 5.10.2 Carbometallacycle formation 5.S.2.2.2 Carbometallacycles from n-allyl complexes 5.S.2.3.9 Carbon reaction with alkali metals 5.10.2.1 Carbon dioxide complexes formation 5.8.2.14.1 Carbon monoxide displacement by alkenes 5.8.2.3.1 Carbonyl complexes by ligand exchange 5.8.2.12.2 from carbon monoxide 5.8.2.12.1, 5.8.2.12.2... 

MBH diene adduct 197, derived from methyl acrylate and crotonaldehyde, has been employed successfully in a palladium-catalyzed asymmetric allylic alkylation (AAA) reaction with Meldrum s acid to provide product 198 that can undergo further manipulations, as well as act as an intermediate in a one-pot tandem palladium AAA reaction. The versatility of these products for various synthetic manipulations was further illustrated by alkene metathesis to form the optically active cyclopentene 201 (Scheme 3.81). ... 

C=C double bonds are cleaved by alkene metathesis reactions [1]. In addition, oxidation of C=C double bonds can also induce their cleavage [48]. For example, an osmium-catalyzed oxidation reaction of fraws-stilbene with oxone produced... 

Total Synthesis by Alkene Metathesis Amphidinolide X (Urpi/Vilarrasa), Dactylolide (Jennings), Cytotrienin A (Hayashi), Lepadin B (Charette), Blumiolide C (Altmann)... 

Hess GD, Hampel F, Gladysz JA (2007) Octahedral gyroscope-like molecules with m(CO)3(X) rotaUns encased in three-spoked diphosphine stators syntheses by alkene metathesis/hydrogenation sequences, structures, dynamic properties, and reactivities. Oiganometallics 26 5129-5131... 

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