Butyryl-CoA dehydrogenase

E. coli C. Kluyveri 4-hydroxy-butyryl-CoA dehydrogenase and R. eutropha phaC P(4HB) 4-hydroxybutyric acid and glucose 68... 

Methyl 3-hydroxy butyric aciduria 2-Methyl 3-hydroxy butyryl-CoA dehydrogenase... 

Butyryl-CoA dehydrogenase formation of long Steyn-Parve and Beinert 19)... 

Fendrich G, Abeles RH. Mechanism of action of butyryl-CoA dehydrogenase-reactions with acetylenic, olefinic, and fluorinated substrate-analogs. Biochemistry 1982 21 6685-6695. 

Matern D, He M, Berry SA, Rinaldo P, Whitley CB, Madsen PP, et al. Prospective diagnosis of 2-methyl-butyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry. Pediatrics 2003 112 74-8. 

Butyryl CoA Dehydrogenase Bovine liver mitochondria Cu 3,450 Mahler (1954)... 

Acyl-CoA dehydrogenase (especially butyryl-CoA dehydrogenase) is irreversibly inactivated by methylene cyclopropylacetyl-CoA through the formation of covalent adduct with the FAD of the enzyme. The inhibitor is derived by transamination... 

Fig. 12. Mechanism proposed for inactivation of butyryl-CoA dehydrogenase by (3-cbloro-3-butenoyl)pantetheine.

Seeley, T.-L. Holmes, R.S. (1981) Biochem. Genet, 19, 333-345 Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bed-1 with Dao-I. 

Prochazka, M. Letter, E.H. (1986) Mouse News Lett, 78, 31. A null activity variant found at the butyryl CoA dehydrogenase (Bcd-l) locus in BALB/cByJ mice. 

Enzymes involved in the biphasic acid and solvent production are shown in Figure 9.1. The respective enzymes for acid production (starting from acetyl-CoA) are phosphotransacetylase (Pta) and acetate kinase (Ack) for acetate, thiolase (ThlA), 3-hydroxybutyryl-CoA dehydrogenase (Hbd), crotonase (Crt), butyryl-CoA dehydrogenase (Bed) coupled to a pair of electron-transferring flavoproteins (EtfA, EtfB), phosphotransbutyrulase (Ptb), and butyrate kinase... 

Figure 9.1 Metabolism and products of sol-ventogenic bacteria. Ack, acetate kinase Adc, acetoacetate decarboxylase AdhE, AdhE2, aldehyde/alcohol dehydrogenase BdhA, BdhB, alcohol dehydrogenase Bed, butyryl-CoA dehydrogenase Buk, butyrate kinase Crt, crotonase CtfA/B, CoA transferase EtfA/B, electron-transfer flavoproteins...

Boynton, Z.L., Bennett, G.N., and Rudolph, EB. (1996) Cloning, sequencing, and expression of clustered genes encoding -hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824. J. Bacteriol, 178, 3015-3024. 

Butyryl-CoA dehydrogenase (green)- FAD— unknown group NADH-cytochrome 5 reductase — FADH2 — NAD... 

FIGURE 9.2 Physiology of ABE fermentation metabolism of Clostridium acetobutylicum with the respective enzymes and products. CoA, coenzyme A Ldh, lactate dehydrogenase Pdc, pyruvate decarboxylase Pfor, pyruvate ferredoxin oxidoreductase Fdred, ferredoxin reduced Thl, thiolase Hbd, p-hydroxybutyryl-CoA dehydrogenase Crt, crotonase Bed, butyryl-CoA dehydrogenase Etf, electron transfer flavoprotein Pta, phosphotransacetylase Ack, acetate kinase Ptb, phosphotransbutyrylase Buk, butyrate kinase Ctf A/B, acetoacetyl-CoA acyl-CoA transferase Adc, acetoacetate decarboxylase AdhE, aldehyde/alcohol dehydrogenase Bdh, butanol dehydrogenase. 

Enoyl CoA hydratase (crotonase) 2 butyryl CoA dehydrogenase 3 Co A-transferase 4 butyraldehyde dehydrogenase 5 butanol dehydrogenase... 

Parker, A. Engel, PC. (1998) Biochem. Soc. Trans. 26, 73S. Experimental evidence for formation of complex between butyryl CoA dehydrogenase and electron transferring flavoprotein. 

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