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Butylmalonic Ester Ethyl

A solution of 200 g. (3.57 moles) of potassium hydroxide (Note 1) in 200 cc. of water is placed in a 2-1. round-bottom flask fitted with a reflux condenser, a mechanical stirrer and a separatory funnel. The stirrer is started and to the hot solution 200 g. (0.92 mole) of ethyl sec.-butylmalonate (Note 2) is added slowly. The solution refluxes gently due to the heat of saponification. After all of the sec.-butylmalonic ester has been added, the solution is refluxed gently for two hours. The solution is diluted with 200 cc. of water and 200 cc. of liquid is then distilled from the solution. This is done in order to remove all of the alcohol formed during the saponification (Note 3). [Pg.76]

Dicyclohexylcarbodiimide n-Butylmalonic acid ethyl ester Hydrazo benzene... [Pg.717]

Into a 2-litre, three-necked flask, fitted with a separatory funnel, a mechanical stirrer and a reflux condenser, place a hot solution of 200 g. of potassium hydroxide in 200 ml. of water. Stir the solution and add slowly 200 g. of ethyl n-butylmalonate (Section 111,154). A vigorous reaction occurs and the solution refluxes. When all the ester has been added, boil the solution gently for 2-3 hours, i.e., until hydrolysis is complete a test portion should dissolve completely in water. Dilute with 200 ml. of water and distil oflF 200 ml. of liquid in order to ensure the complete removal of the alcohol formed in the hydrolysis (1) it is best to connect the flask by means of a wide delivery tube to a condenser set for downward distillation (compare Fig. II, 41, 1 but with a mercury-sealed stirrer in the centre neck). Replace the separatory funnel and the reflux condenser. [Pg.486]

The ethyl sec,-butylmalonate was prepared from sec-butyl bromide and malonic ester according to the general method described in Org. Syn. 4, n. The yield of ester boiling at i24-i32°/28 mm. was 80-81 per cent of the theoretical amount. The yields of 3-methyl pentanoic acid given in this procedure were obtained with this grade of ester. [Pg.77]

The preparation of diethyl butylmalonate380 is an example of alkylation by an alkyl halide A cooled and stirred solution of sodium alkoxide (from 115 g of sodium and 2.5 1 of anhydrous ethanol) is treated gradually with refractionated ethyl malonate (b.p. within 5° 825 g) with further cooling as necessary, this ester is followed by butyl bromide (685 g) during 1 h. Then the solution is heated on a water-bath until neutral to litmus (2-3 h), after which alcohol (21) is distilled off from a water-bath, the residue is treated with its own volume of water, and the organic phase is separated and distilled in a vacuum. A forerun of unchanged malonic ester is followed by the diethyl butylmalonate (89-92%, 960-990 g), b.p. 144-145°/40 mm. [Pg.913]

Allophanate Methyl allophanate Biuret Dimethyl biuret Tetramethyl biuret L-Ascorbic acid 2-(2H-Benzotriazole-2-yl)-4,6-ditertpentylphenol Decanedioic acid, bis(2,2,6,6-tetramethyl-l-(octyl-oxy)-4-piperidinyl)ester Bis (l,2,2,6,6-pentamethyl-4-pi-peridinyl)-[[3,5-bis(l,l-dimethyl-ethyl)-4-hydroxyphenyl]methyl]butylmalonate Tinuvin 328 Tinuvin 123 Tinuvin 144... [Pg.44]

Claisen Condensation Reparation of Ethyl Cinnamateand Cinnamic Acid 9-16. Malonic Ester Synthesis—Preparation of Ethyl-n-Butylmalonate... [Pg.58]

Monoalkylation of malonic ester occurs with primary and some secondary halides in 75-90% yield [16]. An example of the reaction is given for the preparation of ethyl n-butylmalonate [16]. [Pg.75]

Malonic Ester Synthesis—Preparation of Ethyl-n-Butylmalonate 16 ... [Pg.75]


See other pages where Butylmalonic Ester Ethyl is mentioned: [Pg.118]    [Pg.109]    [Pg.11]    [Pg.44]    [Pg.54]    [Pg.118]    [Pg.109]    [Pg.11]    [Pg.44]    [Pg.54]    [Pg.1149]    [Pg.2586]    [Pg.395]    [Pg.1149]    [Pg.486]    [Pg.682]    [Pg.682]    [Pg.486]    [Pg.648]    [Pg.698]   


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Ethyl «-Butylmalonate

N-Butylmalonic acid ethyl ester

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