Butyl-3,5-dimethylaniline

To dispose the highly acidic filtrate safely, a 2.5 cm stir bar should first be placed in an Erlenmeyer flask having a volume two to three times larger than that of filtrate. Then the filtrate is poured into the flask. To the stirred filtrate is added solid Na2C03 (10 g) in small portions so as to avoid extensive foaming. When the last of the solid has been added and CO2 evolution stops, the pH of the solution is taken with pH paper. If the solution is still acidic, mme Na2CC 3 should be added. After the solution is neutralized, it should be transferred into a waste container. 

Record the yield and analyze the erude sample by GC/MS and H NMR spectroscopy, the latter as a solution of the product in CsDs. 

This was the yield obtained by die checkers after distilling their product in vacuum at 85°C and 0.2 mmHg. 

The NMR spectrum of 2,4,6-trimethylpyrylium tetrafluoroborate contains two closely spaced singlets in a ratio very close to 1 4. Explain why there are two fluorine signals and why the ratio is 1 4. 

The nitrogen atom of NH2(f-Bu) is a nucleophile that preferentially attacks atoms in the 2,4,6-trimethylpyrylium ring that are depleted in electron density. A density functional theory calculation on the parent unsubstituted pyrylium cation provides the Merz-Kollman-Singh electrostatic potential-derived charges (MKS EPDC) illustrated in Fig. 1. Which atom(s) of the pyrylium ring are preferentially attacked by the amine  

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M Butylaniline. See Benzenamine, N-(l,l-di-methyletbyl)-, [937-33-7] /VButyl-4- Butyl-aiiiline, 32 127-128 iV-d6- Butyl-3,5-dimethylaniline, 32 124-126... 

The current experiment involves the preparation of the sterically hindered amine A -ferf-butyl-3,5-dimethylaniline. Other preparations of this amine involve addition of methyllithium to lV-3,5-dimethylphenylacetone imine and the reaction of l-bromo-2,4-dimethylbenzene with terf-butylamine either via aryne formation or by palladium-catalyzed alkylation. The current method, the reaction of tert-butylamine with the 2,4,6-trimethylpyrylium cation, involves inexpensive starting materials and proceeds in high yield. The molybdenum(III) complex of the deprotonated form of this amine, Mo[N(f-Bu)(3,5-C6H3Me2)]3, splits the N=N triple bond in N2 to afford molybdenum(VI) nitrido products. This latter reaction is the key step in the recently discovered catalytic process to convert N2 to ammonia under ambient conditions. 

NCi2Hi2D6 OEt2, N-de-tert-huty - i,5-dimethylaniUde etherate, 32 129 NC12H13D6, A-ii6-te -butyl-3,5-dimethylaniline, 32 124 NC14H23, A-terJ-butyl-4-terf-butyl-aiiiline, 32 127... 

Method A. Pit a 1-litre three-necked flask with a mercurj -sealed stirrer, a reflux condenser, and a dropping funnel. Place 57 g. (73-5 ml.) of dry /cr<.-butyl alcohol (1), 101 g, (106 ml.) of A.R. dimethylaniline and 100 ml. of anhydrous ether in the flask, set the stirrer in motion, and... 

Products derived from intermediate zwitter-ions have been obtained in the reactions of benzynes with tertiary amines 1>. Benzyne generated by the reaction of -butyl-lithium with fluorobenzene interacts with AT.Af-dimethylaniline to yield iV-methyl diphenylamine and AT-ethyl diphenylamine 132,133). Using the reaction of chlorobenzene with n-butyl-lithium to generate benzyne resulted in the formation of increased amounts of 2-A7,AT-dimethylaminobiphenyl 132,133)... 

In a 2-1. flask equipped with a reflux condenser, mercury-sealed stirrer, and a dropping funnel are placed 147 ml. (114 g., 1.5 moles) of ferf.-butyl alcohol (Note 1), 212 ml. (202 g., 1.67 moles) of dimethylaniline, and 200 ml. of dry ether. The solution is heated to refluxing, and 113 ml. (124 g., 1.58 moles) of acetyl chloride is run into the stirred solution at such a rate that moderate refluxing continues after the source of heat is removed. When approximately two-thirds of the acetyl chloride has been added, dimethylaniline hydrochloride begins to crystallize and the mixture refluxes very vigorously. An ice bath is applied immediately, and, after refluxing ceases, the remainder of the acetyl chloride is added. Finally, the mixture is heated for 1 hour on a water bath. The mixture is cooled to room tempera-... 

The other method results directly from the piperidine-2-carboxylic acid chloride, which is reacted with 2,6-dimethylaniline. The resulting amide (2.2.8) is further alkylated with butyl bromide to bupivacaine [17-19]. 

If both had the sandwich pair structure 17, the exciplex formed with N,N-dimethylaniline should be considerably more stable because it would have less steric interference. On the other hand, if both had a structure analogous to 18, 3,5-di-f-butyl-N,N-dimethylaniline should form the more stable exciplex because of the electron-donating ability of the f-butyl groups.)... 

Fig. 19. Molecular structure of polytriacetylenes (PTA). The conjugation ends are substituted by donor (dimethylaniline) and acceptor (nitrophenyl) groups to modify the nonlinear optical properties. The lateral OTBDMS ((ferf-butyl)dimethylsilyloxyl) groups serve for improved solubility in the solvent (typically chloroform)...

An investigation of the spectral and kinetic characteristics of radical cations of para-halogeno-A,A-dimethylanilines and / ara-halogenodiphenylamines in water/terr-butyl alcohol has been performed in view of the fact that such species are probable intermediates in photonucleophilic substitution of halogen638. Bathochromic shifts in the absorption maxima of the radical cations were observed in the order H=F < Cl < Br. The disappearance of the radical cations obeys second-order kinetics and the rate constants are close to the diffusion-controlled values. The radical cations arise from the singlet excited states of the halogenoarylamines and homolysis of the carbon-halogen bond competes with their formation. 

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