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Butorphanol tartrate

Morphinan derivatives butorphanol tartrate nalbuphine hydrochloride... [Pg.626]

Butorphanol tartrate is a weak partial p-receptor agonist, 3.5-5 times as potent as morphine. The incidence of psychotomimetic effects is relatively low. The recommended doses are 1-4 mg intramuscularly every 3-4 h or 0.5-2 mg intravenously. Respiratory depression produced by butorphanol 2 mg IV is similar to that of 10 mg morphine. However, there is a ceiling effect for respiratory depression, and near-maximum depression occurs after 4 mg in normal adults. In healthy volunteers, butorphanol 0.03-0.06 mg-kg-1 produces no significant cardiovascular changes. However, in patients with cardiac disease, progressive increases in cardiac index and pulmonary artery pressure occur, and butorphanol should be avoided in patients with recent myocardial infarction. Butorphanol is metabolised mainly in the liver to inactive metabolites. The terminal half-life is 2.5-3.5 h. [Pg.132]

Ameer, B., Salter, F. J. Drug therapy reviews evaluation of butorphanol tartrate, Am. J. Hosp. Pharm. 1979, 36, 1683-1691. [Pg.230]

Figure 6.43 Degradation pathway for butorphanol tartrate in long-term stability samples (LTSS). The dashed area indicates the substructure involved in the proposed ring contraction. (Reprinted with permission from Volk et al., 1996. Copyright 1996 Elsevier.)... Figure 6.43 Degradation pathway for butorphanol tartrate in long-term stability samples (LTSS). The dashed area indicates the substructure involved in the proposed ring contraction. (Reprinted with permission from Volk et al., 1996. Copyright 1996 Elsevier.)...
Volk, K. J. Klohr, S. E. Rourick, R. A. Kerns, E. H. Lee, M. S. 1996. Profiling impurities and degradants of butorphanol tartrate using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry substructural techniques. J. Pharm. Biomed. Anal., 14,1663-1674. [Pg.230]

Butorphanol Tartrate With this drug, dependence, withdrawal, and interactions are similar to that of opioids. Butorphanol has less potential to produce dependence when compared with morphine, but it is a drug of abuse. Naloxone acts as an antagonist and can be used for the treatment of overdose.35... [Pg.340]

Infra-red Spectrum. Principal peaks at wavenumbers 1269,1130, 1233, 1575, 1249, 1303 (butorphanol tartrate, KBr disk). (See below)... [Pg.417]

Dose. 1 to 4 mg of butorphanol tartrate every 4 hours by intramuscular injection doses of 4 to 16 mg have been given by mouth. [Pg.418]

Ajmaline Hydrochloride 454.1 Dofamium Chloride 477.6 Butorphanol Tartrate... [Pg.1082]

Ethopropazine Hydrochloride 217-219d Butorphanol Tartrate 227-228d Carbazochrome Sodium ... [Pg.1091]

Butobarbital, 416 Butobarbitone, 416 Butoforme, 419 Butorphanol, 417 Butorphanol tartrate, 417 Butoxamine, xvii... [Pg.1238]

Stick J A, Loeffler B S, Arden W A et al 1989 Effects of butorphanol tartrate on arterial pressure, jejunal blood flow, vascular resistance, O2 extraction, and O2 uptake in halothane-anesthetized ponies. American Journal of Veterinary Research 50 1202-1206 Stimpfel T M, Gershey E L 1991 Selecting anesthetic agents for human safety and animal recovery surgery. Federation of American Societies for Experimental Biology Journal 5 2099-2104... [Pg.308]

STADOL NS BMS (U.S.) Butorphanol tartrate NaCI, cit, BzCI, NaOH, HCI (pH 5) 10 mg/mL active solution... [Pg.493]

See other pages where Butorphanol tartrate is mentioned: [Pg.1055]    [Pg.535]    [Pg.99]    [Pg.25]    [Pg.167]    [Pg.191]    [Pg.171]    [Pg.132]    [Pg.23]    [Pg.385]    [Pg.169]    [Pg.417]    [Pg.418]    [Pg.1145]    [Pg.498]    [Pg.946]    [Pg.247]    [Pg.368]    [Pg.750]    [Pg.58]    [Pg.250]    [Pg.251]    [Pg.32]    [Pg.916]    [Pg.117]    [Pg.117]    [Pg.117]   
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See also in sourсe #XX -- [ Pg.946 ]

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See also in sourсe #XX -- [ Pg.32 ]

See also in sourсe #XX -- [ Pg.493 ]

See also in sourсe #XX -- [ Pg.117 ]

See also in sourсe #XX -- [ Pg.317 , Pg.320 , Pg.337 ]

See also in sourсe #XX -- [ Pg.63 ]



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