Sumatriptan Butorphanol

No pharmacokinetic interactions or change in adverse effeets were found to oeeur between single 1-mg doses of butorphanol tartrate nasal spray and a 6-mg subeutaneous dose of sumatriptan sueeinate in 24 healthy subjects. It was concluded that concurrent use during aeute migraine attacks need not be avoided. ... 

In another study, 19 healthy subjeets were given a 1-mg dose of butorphanol nasal spray either 1 or 30 minutes following a 20-mg dose of sumatriptan nasal spray. When butorphanol was given 1 minute after sumatriptan the AUC and maximum plasma levels of butorphanol were reduced by about 29% and 38%, respeetively. When butorphanol was given 30 minutes after sumatriptan no signifieant pharmaeokinetic interaction was noted. It was suggested that sumatriptan may eause a transient vasoconstriction of nasal blood vessels, leading to redueed butorphanol absorption. It would therefore seem wise to separate administration to ensure the full effects of butorphanol are aehieved. ... 

Srinivas NR, Shyu WC, Upmalis D, Lee JS, Barbhaiya RH. Lack of pharmacokinetic interaction between butorphanol tartrate nasal spray and sumatriptan succinate. J Clin Pharmacol (1995)35,432-7. 

Vachharajani NN, Shyu W-C, Nichola PS, Boulton DW. A pharmacokinetic interaction study between butorphanol and sumatriptan nasal sprays in healthy subjects importance of the timing of butorphanol administration. Cephalalgia (2002) 22,282-7. 

Sumatriptan given by injection appears not to interact with butorphanol nasal spray, but if both drugs are given sequentially by... 

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