1- Butanone, 3-hydroxy-3-methyl-1-phenyl

HYDR0XY-3-NETHYL-1-PHENYL-1-BUTAN0NE BY CROSSED ALDOL REACTION (1-Butanone, 3-hydroxy-3-methyl -1-phenyl -)... 

HYDROXY-3-METHYL-1-PHENYL-1-BUTANONE 1-BUTANONE, 3-HYDROXY-3-METHYL-1-PHENYL- (43108-74-3), 65, 6, 12 1-(3-HYDROXY-2-METHYL-3-PHENYLPROPANOYL)PIPERIDlNE, ERYTHRO PIPERIDINE, 1 -(3-HYDROXY-2-METHYL-1-OXO-3-PHENYLPROPYL)-, R, R )-( )- (99114-36-0), 69, 44 N-Hydroxymethylphthalimide Phthalimide, N-(hydroxymethyl)- ... 

FLUOROPHENYL)-4-(4-HYDROXY-4-(3-(TRIFLUORO-METHYL)PHENYL)-l-PIPERIDINYL)-l-BUTANONE MCN-JR-2498 PSICOPERIDOL-R PSYCHOPERIDOL R-2498 TRIFLUPERIDOLO (ITALIAN) TRIPERIDOL... 

C10H11NO2 (4S,5R)-(-)-4-methyl-5-phenyl-2-oxazoltdinone 16251-45-9 25.00 1.1399 2 19560 Cl OH1202 4-hydroxy-1-phenyl-1-butanone 39755-03-8 21.78 1.0624 2... 

Acetyl-2,4-dihy droxy-6-methoxy-5-methylpheny l)methyl]-3,4-dihydro-3,5,7-trihydroxy-2,2-dimethyl-2H-1 -benzopyran-8-yl] -2-methyl-1 -propanone, 2163 1 - [3 - [(3 - Acetyl-2,4-dihydroxy-6-methoxy-5-methylphenyl)methyl] -2,4,6-trihydroxy-5-(2-hydroxy-3-methyl-3-butenyl)phenyl]-2-methyl-1 -propanone, 2163 l-[2,4,6-Trihydroxy-3-(2-methyl-l-oxopropyl)-5-[[2,4,6-trihydroxy-3-methyl-5-(1 -oxobutyl)-phenyl]methyl]phenyl] -1 -butanone, 2164... 

Hydroxy-3-methyl-1-phenyl-1-butanone is too unstable to be purified by distillation, and is decomposed to acetophenone and acetone. 

A. Isopvopylidensaaetophenone. A 1-L, three-necked flask is fitted with a 100-mL pressure-equalizing dropping funnel, a mechanical stirrer and a condenser which is equipped with a two-way stopcock leading to a balloon of argon gas. To the flask is added a solution of 18,4 g of 3-hydroxy-3-methyl-1-phenyl-1-butanone (Note 1) in 60 mL of dry methylene chloride. The flask is cooled 1n an ice bath and 28.5 g of trlethylamine, a catalytic amount of 4-(N,N-dimethylamino)pyridine and 20 mL of methylene chloride are added. A solution of 25.8 g of trlfluoroacetic anhydride (Note 2) in 40 mL of methylene chloride Is added dropwlse over a period of 15 min, and the mixture is stirred for 2. 5 hr. ... 

HYDROXY-3-METHYL-1-PHENYL-1-BUTANONE BY CROSSED ALDOL REACTION... 

SYNS 2-BUTANONE, 4-(4-HYDROXY-3-xMETHOXY-PHENYL)- GINGERONE 4-(4-HYDROXY-3-METHOXYPHENYL)-2-BUTANONE (4-HYDROXY-3-METHOXYPHENYL)ETHYL METHYL KETONE 3-METHOXY-4-HYDROXY-BENZYLACETONE (0)-PARADOL ZINGERONE ZINGIBERONE... 

CIC The powerful odour is dominated by 2-isobutyl thiazole and 3-pentanethiol. The green notes are lipid degradation products like (E)-2-hexenal, hexanal and higher unsaturated aldehydes, the pineapple-pear like fruity notes are derived from methyl hexanoate, ethyl-2-hexenoate and hexyl acetate. The spicy cinnamon notes are represented by 3-phenyl propyl acetate, cinnamyl acetate, methyl cinnamate, ethyl cinna-mate and ciimamaldehyde. Gamma-decalactone and 2,5-dimethyl-4-hydroxy-furan-3(2H)-one and 3-hydroxy-2-butanone add the sweet, creamy body. Beta-famesene, citronellol, 2-phenylethanol, beta-ionone add the sweet, floral, quincelike part and methyl benzoate and ethyl benzoate impart a characteristic medicinal, exotic topnote. 

Thionyl diloride added below 0 to dimethylformamide, the resulting soln. mixed with l-amino-l-phenyl-2-butanone hydrochloride, and heated 1.5-2 hrs. at 60-90° on a water bath after the initial exothermic reaction has ceased 4-hydroxy-5-methyl-3-phenylisothiazole. Y 78%. F. e., also with sulfur monodiloride, s. T. Naito et al., Bull. Chem. Soc. Japan 41, 959, 965 (1968). 

Hydroxy 2-methyl 1-phenyl 1-propanone 4-(p-Hydroxyphenyl)-2-butanone Isoeugenol Isopropyl benzoate 1 -(p-Methoxyphenyl)-2-propanone 4-Methyl benzyl acetate a-Methylbenzyl acetate -a-Methylbenzyl acetate Methylbenzyl acetate, mixed o-, m-, p-Methyl 3-phenylpropionate... 

An autoclave charged with 3-hydroxy-3-methyl-2-butanone, benzaldehyde, GaCla, and NH4GI, anhydrous NHg introduced with stirring until a pressure of 80 p.s.i.g. is obtained, then heated 4 hrs. at 90-100°/300-400 p.s.i.g. 2-phenyl-4,5,5-trimethyl-3-oxazoline. Y 96%. F. e. s. J. R. Gaines and G. R. Hansen, J. Heterocyclic Ghem. 96 (1964). 

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