Busulfan seizures with

Busulfan Seizures, busulfan concentrations if being used with the BU-CY preparative regimen, number of vomiting episodes, nausea by patient self-report... 

Busulfan Nausea and vomiting rarely diarrhoea Bone marrow depression pulmonary infiltrates and fibrosis alopecia gynaccomasiia ovarian failure hyperpigmentation azoospermia leukaemia chromosome aberrations cataracts hepatitis seizures and veno-occlusive disease with high doses... 

Bone marrow recovery may be delayed (3-6 weeks) pulmonary fibrosis associated with >3 years exposure, prior chest radiation seizure prophylaxis (phenytoin 300 mg/day with BMT doses) Pharmacokinetic monitoring is required with IV busulfan, preferably in an experienced BMT setting... 

High doses of busulfan also have been used effectively in combination with high doses of cyclophosphamide to prepare leukemia patients for bone marrow transplantation. In such high-dose regimens, busulfan is given at 0.8 mg/kg every 6 hours for 4 days. Anticonvulsants must be used concomitantly to protect against acute CNS toxicities, including tonic-clonic seizures, which may occur... 

The toxic effects of busulfan are related to its myelosuppressive properties prolonged thrombocytopenia may occur. Occasional patients experience nausea, vomiting, and diarrhea. Longterm use leads to impotence, sterility, amenorrhea, and fetal malformation. Rarely, patients develop asthenia and hypotension. High-dose busulfan causes VOD of the liver in up to 10% of patients, as well as seizures, hemorrhagic cystitis, alopecia, and cataracts. The coincidence of VOD and hepatotoxicity is increased by its coadministration with drugs that inhibit CYPs, including imidazoles and metronidazole, possibly by inhibition of the clearance of busulfan and/or its toxic metabolites. 

Alkylating agents Busulfan D+, En+, G+, M+, N+, P++ Acute overdose of 2.4 g was fatal in a 10-year-old. High doses can cause coma, seizures. Hemodialysis may be effective. Pulmonary fibrosis, adrenal insufficiency with chronic use. 

The development of seizures in patients taking ciclosporin after bone marrow transplants has been attributed to previous treatment with busulfan and cyclophosphamide. Cyclophosphamide was found to reduce ciclosporin levels. 

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