Burow’s solution

Monobasic aluminum acetate is dispensed as a 7% aqueous solution for the topical treatment of certain dermatological conditions, where a combination of detergent, antiseptic, astringent, and heat-dispersant effects are needed (12). The solution, diluted with 20—40 parts water, is appHed topically to the skin and mucous membranes as a wet dressing (13). Burrow s solution, prepared from aluminum subacetate solution by the addition of a specific amount of acetic acid, is also used as a topical wet dressing. Standards of purity and concentration have been estabHshed for both pharmaceutical aluminum acetate solutions (13). Each 100 mL of aluminum subacetate solution yields 2.30—2.60 g of aluminum oxide and 5.43—6.13 g of acetic acid upon hydrolysis. For the Burow s solution, each 100 mL yields 1.20—1.45 g of aluminum oxide and 4.25—5.12 g of acetic acid. Both solutions may be stabilized to hydrolysis by the addition of boric acid in amounts not to exceed 0.9% and 0.6% for the subacetate and Burow s solutions, respectively (13). 

Aluminum acetate (Burow s solution), calamine, and witch hazel are safe and effective products available for use.25 Patients apply solutions as a compress for 15 to 30 minutes two to four times a day. 

The boy had recently been playing more outside in the yard, due to the hot weather, and his mother asked if the rash could have been caused by chiggers (larvae of mites that attached to the skin). With the patient s history of playing outdoors, and the characteristic linear vesicles, the doctor believed that the child had an allergic contact hypersensitivity reaction to poison ivy, and instructed the mother to apply cloths soaked in Burow s solution (aluminum acetate) until the vesicles crusted over. The mother was also told to thinly apply1% hydrocortisone cream (a low potency steroid) twice per day. 

Following dermal exposure to chloropicrin, the exposed area must be washed thoroughly with soap and water. If dermatitis persists, topical treatment with wet dressings of Burow s solution 1 40, followed by corticosteroid creams or calamine lotion, may be given. Secondary infection may necessitate antibiotic therapy. Oral antihistamines may be useful for pruritis. 

Aluminum Acetate Solution. Burow s Solution Domeboro. Contains about 5% neutral aluminum acetate. A (CjHjOj) = 0.66% Al, 4.4% acetic acid (1.25% A12Oj> Prepn from a dry mix consisting of an alkali metal acetate, acetic acid and a dibasic aluminum acetate stabilized with boric acid Gibbons et al, U.S. pat. 2,824,042 (1958). 

Aluminum acetate solution Burow s solution Buro-Sol Concentrate Domeboto component of Otic Domeboro See [139-12-8]. Aluminum acetate. Antiseptic (topical) astringent. Colorless liquid d 1.002 pH (1 20 aqueous solution) = 4.2. Doak Pharmacal Co. Inc. Miles Inc. 

At the first sign of contact dermatitis, clean the skin area immediately. Patch testing may be needed to determine the causative factor. Apply wet dressings containing Burow s solution (aluminum acetate), lotions such as calamine that contain zinc oxide, calcium hydroxide solution, and glycerin. Calamine lotion may contain the antihistamine diphenhydramine and is used primarily for plant irritations. If itching persists, antipraritics (topical or systemic diphenhydramine [Benadryl]) may be used. Topical antipraritics should not be applied to open wounds or near the eyes or genital area. 

Hydrogen peroxide is not used to cleanse impetigo. A 1 20 Burow s solution may be used to put compresses on the impetigo. 

For dermatitis, a topical steroid preparation (eg, triamcinolone acetonide, fluocinolone acetonide, flurandrenolone, or betamethasone-17-valerate) is the principal therapeutic agent. Oozing lesions should be treated with wet dressings (moistened with fluids such as 1 40 Burow s solution). Appropriate antibiotics should be given for secondary infection, and oral antihistamines for itching.13 Vesicating lesions have been successfully treated with compresses of a cold silver nitrate solution (1 1,000)... 

Burow.S. P., Peterlin, A., Turner, D.T. The upturn effect in the non-newtonian viscosity of polymer solutions. Polymer (London) 6. 35-47 (1965). 

Burow, S.7 Peterlin, A. Turner D.T. Increasing viscosity of polymer solutions with increasing shear stress. Polymer letters 2 (1964) 67-70... 

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