Burk, Dean

Obayashi M, Ito E, Matsui K, Kondo (1982) Tetrahedron Lett 23 2323 Halazy S, Gross-Berges V (1992) J Chem Soc Chem Comm p 743 Lequeux TP, Percy JM (1995) SYNLETT p 361 Bigge CF, Drummond JT, Johnson G (1989) Tetrahedron Lett 30 7013 Halazy S, Ehrhard A, Danzin C (1991) J Am Chem Soc 113 315 Martin SF, Dean DW, Wagman AS (1992) Tetrahedron Lett 33 1839 Otaka A, Miyoshi K, Burke TR, Roller PP, Kubota H, Tamamura H, Fujii N (1995) Tetrahedron Lett 36 927... 

Burke, D.F., Deane, C.M. and Blundell, T.L. (2000) Browsing the SLoop database of structurally classified loops cormecting elements of protein secondary structure. Bioinfomatics 16 513-519. 

The most commonly used transformation of the Michaelis-Menten equation is that due to Hans Line-weaver and Dean Burk. Their equation was introduced in 1934 by taking reciprocals of both sides of Eq. (5.9) we obtain... 

In 1934, Dean Burk (1904-88) and Hans Lineweaver (1907- ), at the United States Department of Agriculture, proposed an extremely simple mathematical solution to this experimental problem. By simply plotting the reciprocals of... 

One product of a post-seminar discussion of Ren Dubos, George Wald and Dean Burk was the work on hydrocarbon metabolizing bacteria by Turkevich, Goodale and F. Johnson.(2)... 

For the convenience of graphic presentation of experimental data Hans Lineweaver (1907-2009) and Dean Burk (1904-1988) modified equation... 

Hans Lineweaver and Dean Burk, emphasized the uncertainty of large l/v values and suggested to apply smaller weightings for these values. Problems arise specifically for small substrate concentrations resulting in slow reaction rates. When the reaction rates are particularly small 1) the reciprocal value becomes very large, as does the error of this value. 

Characteristic Quantities In principle, the quantities and ro,max that characterize an enzyme can be determined by directly fitting the Michaelis-Menten equation to the measured data using computer supported methods of nonlinear regression. We can simplify the analysis in a manner suggested by Hans Lineweaver and Dean Burke in 1934 by linearizing the relation. In order to do this, we must find the reciprocal of the Michaelis-Menten equation. After transforming, we have ... 

Lineweaver-Burk plot A double-reciprocal plot used to determine the two constants featured in simple enzyme kinetic equations such as Michaelis-Menten kinetics, Monod kinetics, and in similar adsorption isotherm models such as the Langmuir adsorption isotherm. The constants are determined from the intercept with the y-axis and the gradient (see Fig. 26). It was devised and published in 1934 by American chemist Hans Lineweaver (1907-2009) and American biochemist Dean Burk (1904-1988). 

Prior to the development of rapid methods for data treatment, Hans Lineweaver and Dean Burk proposed a simple method using the reciprocals of eq. (14.13) to obtain experimentally the values of and Ky [4],... 

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