Buddleja cordobensis

An evaluation of antiviral properties of various EOs from South American plants was carried out by Duschatzky et al. (2005). The authors assessed the cytotoxicity and in vitro inhibitory activity of the EOs against HSV-1, DENV-2, and JUNV by a virucidal test. The best results were observed with the EOs of Heterothalamus alienus (Asteraceae) and Buddleja cordobensis (Scrophulariaceae) against JUNV, with virucidal concentration 50% (VC50) values of 44.2 and 39.0 ppm and therapeutic indices (cytotoxicity to virucidal action ratio) of 3.3 and 4.0, respectively. The oils caused the inhibitory effect interacting directly with the virions. 

Catalpol (18) isolated from Buddleja cordobensis showed a series of allelochemical effects related to DNA synthesis in the insect Tribolium castaneum by inhibition of tag DNA polymerase activity with an IC50 value of 47.8 pM. Thus, it exhibited post-ingestive toxic effects showing a reduction in the efficiency of conversion of injected food [177]. 

---