Buclizine hydrochlorid

Along similar lines, the presence of related substances found in pharmaceutical drugs may be estimated by using HPLC method, for examples atenolol, buclizine hydrochloride, ibuprofen, and the like. 

Common Name Buclizine hydrochloride Histabutazine Histabutizine... 

FIGURE 1.1 X-ray powder diffraction pattern of buclizine hydrochloride. 

Test A The infrared absorption spectrum. Appendix IIA, is concordant with the reference spectrum of buclizine hydrochloride RS 032). 

Carry out the method for liquid chromatography. Appendix HID, using four solutions in the initial mobile phase containing (1) 0.001% (w/v) of buclizine hydrochloride (2) 0.50% (w/v) of buclizine hydrochloride ... 

The test is not valid unless the chromatogram obtained with solution (4) closely resembles the chromatogram supplied with buclizine hydrochloride impurity standard BPCRS. 

Tang [16] described an improved method for thin layer chromatographic identification of compound buclizine. Compound buclizine contains mainly buclizine hydrochloride, bromhexine hydrochloride, and promethazine hydrochloride. A 20 ml portion of sample solution was made alkaline with 0.05 M sodium hydroxide (2.5 ml) and extracted with chloroform (5 ml). Standard solution of buclizine hydrochloride, bromhexine, hydrochloride, and promethazine together or separately were similarly prepared. The chloroform solution were spotted on to Silica gel G plates (previously treated with 0.5% sodium hydroxymethylcellu-lose solution and activated at 100 °C for 1 h) with chloroform methanol ... 

Siddiqui et al. [28] developed and validated an analytical spectral calibration method to quantify buclizine hydrochloride, which is a piperazine derivative and used a single active principle in pharmaceutical forms were done. The quantification of buclizine hydrochloride was performed in the wavelength range of 218-226 nm at N = 6. The linear regression equation has been constructed using relationship between concentration and absorbance at 218, 220, 222, 224, and 226 nm. 

Arun et al. [30] developed and validated a rapid high-performance liquid chromatographic method for the estimation of buclizine hydrochloride in tablet dosage form. The stationary phase used was precoated silica gel 60 F254. The mobile phase used was a mixture of methanol chloroform ammonia (8 1 1). The detection of spots was carried out at 234 nm. The method was validated in terms of linearity, accuracy, precision, and specificity. The calibration curve was linear between 100 and 700 ng/spot. The limit of detection and the limit of quantification were 20 and 100 ng/spot, respectively. The method can be used to determine the drug content of tablet dosage formulation. 

Buclizine Hydrochloride, USP. Buclizine hydrochloride. l-(/z-rerrbutylbenzyl)-4-(p-chloro-a-phenylbenzyl)pip-erazine dihydrochloride (Bucladin-S). occurs as a white to slightly yellow crystalline powder that is insoluble in water. The highly lipid-soluble buclizine has CNS depressant, antiemetic, and antihistaminic properties. The. salt is available in SO-mg tablets for oral administration. The usual dose is SO mg 30 minutes before travel and is repeated in 4 to 6 hours as needed. 

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