Bruton tyrosine kinase

X-Linked agammaglobulinemia Defect in gene coding for Bruton tyrosine kinase responsible for B cell growth and maturation. 

Haire RN, Ohta Y, Strong SJ, Litman RT, Liu YY et al (1997) Unusual patterns of exon skipping in bruton tyrosine kinase are associated with mutations involving the intron 17 3 splice site. Am J Hum Genet 60 798-807... 

Case study Rapid Optimization of Expression Conditions and Large-scale Production of a Brutons Tyrosine Kinase Variant (BTK)... 

Bromodeoxyuridine (BrdU) 641, 1261 6-Bromoindirubin-3-oxime 288 Brutons tyrosine kinase variant (BTK) 1053 BSE see Bovine spongiform encephalopathy B-type polymerase... 

Btk (Bruton s tyrosine kinase) is a phosphatidylinositol 3 -kinase sensitive cytoplasmic tyrosine kinase. Germline loss of function mutations of Btk cause X-linked agammaglobulinaemia in human and X-linked immunodeficiency in mice. 

BTK Bruton s tyrosine kinase Cys-rich motif E(M) 0(0) 0(0) 1B55... 

A variety of domain or motif families occur only as extensions to other domains. The Bruton s tyrosine kinase motif (BTK), for example, is found only at the C terminus of PH domains. Similarly, a C-terminal extension (the S TK X domain) to some subfamilies of serine/threonine kinases (S TK) is not found in isolation. Cases where only the extension, and not the preceding domain, is found are strong evidence that the proteins are wrongly assembled from genomic sequence or else represent partial cDNA sequences (Fig. 9, see Color insert). Indeed, all five proteins annotated in SMART as containing a S TK X domain with no catalytic domain are noted to be fragments in their corresponding sequence database entries. 

Human Bruton s tyrosine kinase IBTK HiSa/i 10 CySa/i 0 CyS2a/i 9 Cysb/i... 

E. Baraldi, K.D. Carugo, M. Hyvonen, P.L. Surdo, A M. Riley, B.V. Potter, R. O Brien, J.E. Ladbury, and M. Saraste. 1999. Structure of the PH domain from Bruton s tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate... 

PBKs phosphorylate inositol lipids at the 3 position of the inositol ring to generate the 3-phosphoinositide PI(3,4,5)P3, (PIP3). PBKs of class IB are directly activated by GP t, but others PBK also belong to pathways of receptors with or coupled to tyrosine kinase activity. PIP3 may recruit to tlie membrane various protein kinases, phosphoinositide-dependent kinase-1 (PDK-1), protein kinase B (PKB, or Akt), protein kinase (PKCQ, PLC t and cytosolic tyrosine kinases such as the Bruton s tyrosine kinase (Btk). 

X-linked agamma-globulinaemia (XLA) lack of mature immunoglobulin-producing B cells Mutations in Bruton s tyrosine kinase (BTK) Arthritis, dermatomyositis, autoimmune haemolytic anaemia (AIHA), scleroderma... 

Baba, K. Takeshita, A. Majima, K. Ueda, R. Kondo, S. Jimi, N. Yamamoto, D. The Drosophila Bruton s tyrosine kinase (Btk) homolog is required for adult survival and male genital formation. Mol. Cell. Biol., 19, 4405-4413 (1999)... 

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