Bruice

Hansma H G, Sinsheimer R L, Groppe J, Bruice T C, Elings V, Gurley G, Bezanilla M, Mastrangelo I A, Hough P V C and Hansma P K 1993 Recent advances in atomic force microscopy of DMA Scanning 15 296... 

T. C. Bruice and S. I Benkovic, Bioorganic Mechanisms, Vol. 1, W. A. Benjamin, New brk, 1966, pp. 1-258 W. P. Jencks, Catalysis in Chemistry and Enzymology, McGraw-Hill, New York, 1969 M. L. Bender, Mechanisms of Homogeneous Catalysis from Protons to Proteins, Wiley-Interscience, New York, 1971 C. Walsh, Enzymatic Reaction Mechanisms, W. H. Freeman, San Francisco, 1979 A. Fersht, Enzyme Structure and Mechanism, 2nd ed., W. H. Freeman, New York, 1985. 

The method is quite effective, but is not widely used now because of the ubiquity of digital computers. Zuman and Patel - 36. show circuit designs for some kinetic schemes. Williams and Bruice made good use of the analog computer in their study of the reduction of pyruvate by 1,5-dihydroflavin. In this simulation eight rate constants were evaluated variations in these parameters of 5% yielded discemibly poorer curve fits. 

Books by Bruice and Benkovic/ Jencks, and Bendei are rich sources of examples of catalytic processes and their mechanisms. 

Kaaret, T. W., and Bruice, T. C. (1990). Electrochemical luminescence with N(5)-ethyl-4a-hydroxy-3-methyl-4a,5-dihydrolumiflavin. The mechanism of bacterial luciferase. Photochem. Photobiol. 51 629-633. 

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