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7- Bromopropylphthalimide

In a 500-ml. distilling flask arc placed 107 g. (0.40 mole) of 7-bromopropylphthalimide (Note 1) and 240 ml. of xylene. Solution is effected by heating, and 24 ml. of xylene is distilled to remove traces of moisture. After cooling, the solution is transferred to a 1-1. round-bottomed flask with a ground-glass joint and treated with 107 g. (140 ml., 0.83 mole) of di- -buty]amine. [Pg.23]

The 7-bromopropylphthalimide was prepared from potassium phthalimide and trimethylene bromide in 78% yields, using the conditions and molar quantities specified for the preparation of (3-bromoethylphthalimide.1 7-Bromopropylphthalimide can also be prepared from phthalimide, potassium carbonate, and trimethylene bromide.2... [Pg.24]

CXXIV), a conclusion later confirmed by the synthesis of the base (195). 7-Bromopropylphthalimide (CXXV) reacts with the potassium derivative of ethyl butyroacetate (CXXVI) affording 5-phthalimino-a-carbethoxy-... [Pg.223]

Bromophthalide, 23, 74 0-Bromopropionic acid, 20, 65 y-Bromopropylphthalimide, 24, 44, 46 N-(7-Bromopropyl)-tetrahydroquino-line, 26, 41... [Pg.51]

Polyamine chain extension, 48-56 by acrylamide 51, 52. 53 by aziridine 48,49 by l-bromo-3-chloropropane, 55 by (2-bromoethyl)phthalimide, 51 by 3-bromopropylphthalimide, 53 by chloroacetonitrilc, 51 by chloroacetyl chloride. 50 by lV-(2-chloroethyl)acetamide, 52 by derivatives of chloroacetic acid. 50 by dichloro(o)-bromoalkyl)boranes. 56 by IV-ethylchloroacetamide, 52 by 3-phthalimidopropyl tosylate, 54 by /V-tosyl-2-bromoethylamine, 49 by 2-(N-tosylamino)ethyl tosylate. 49 by Af-tosylaminoacetyl chloride, 50 Polyamino diols. 59 Polyaza-crown macrocycles. 349-367 alkyl-substituted. 364.365 from bis-sulfonamides, 358-361 from diacid dichlorides, 352-357 from diesters, 352-357 from dihalides, 362-366 from diols, 366 from ditosylates. 362-366 Polyaza-crown macrocycles (miscellaneous), table. 392... [Pg.882]

Scheme 10 Synthesis of oxiized trypanothione (46). Either the di-Boc- or the Boc-Fmoc-spermidine is coupled to the resin 111. After deprotection, the primary amines are further derivatized [162,163,215]. Reagents and conditions a Boc-HN-(CH2)30Ts or 3-bromopropylphthalimide, Na2C03, KI, n-BuOH b Pd/C, H2, EtOH, AcOH c O-(p-nitrophenyl)-0 -(methoxycarbonyl)benzylcarbonate, NEt3, DMF, 97% d aq. NaOH, dioxane in the case of R = Pht N2H4 H2O, EtOH then Fmoc-succinimide e DIG, HOBt, DMAP, aminomethyl resin, DMF or CH2CI2 / deprotection, Fmoc-AS-peptide coupling g TFA/TFMSA/ethanedithiol/PhSMe 12/MeOH [162]... Scheme 10 Synthesis of oxiized trypanothione (46). Either the di-Boc- or the Boc-Fmoc-spermidine is coupled to the resin 111. After deprotection, the primary amines are further derivatized [162,163,215]. Reagents and conditions a Boc-HN-(CH2)30Ts or 3-bromopropylphthalimide, Na2C03, KI, n-BuOH b Pd/C, H2, EtOH, AcOH c O-(p-nitrophenyl)-0 -(methoxycarbonyl)benzylcarbonate, NEt3, DMF, 97% d aq. NaOH, dioxane in the case of R = Pht N2H4 H2O, EtOH then Fmoc-succinimide e DIG, HOBt, DMAP, aminomethyl resin, DMF or CH2CI2 / deprotection, Fmoc-AS-peptide coupling g TFA/TFMSA/ethanedithiol/PhSMe 12/MeOH [162]...
See other pages where 7- Bromopropylphthalimide is mentioned: [Pg.57]    [Pg.100]    [Pg.53]    [Pg.57]    [Pg.263]    [Pg.16]    [Pg.100]    [Pg.53]    [Pg.50]    [Pg.287]    [Pg.1163]   
See also in sourсe #XX -- [ Pg.24 , Pg.44 , Pg.46 ]

See also in sourсe #XX -- [ Pg.24 , Pg.44 , Pg.46 ]

See also in sourсe #XX -- [ Pg.24 , Pg.44 , Pg.46 ]



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Y-Bromopropylphthalimide

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