2-Bromo-2-nitro-propane-1,3-diol Bronopol

Bromo-2-nitro-1,3-propane-diol Bronopol CgHgBrNOg 52-51-7 199.989 131.5 ... 

Synonyms BNPD 2-Bromo-2-nitro-propan-1,3-diol 2-Bromo-2-nitro-1,3-propanediol P-Bromo-P-nitrotrimethylene glycol Bronopol 1,3-Propanediol, 2-bromo-2-nitro ClassiTication Substituted aliphatic diol Empiricai CjHsBrNO,... 

Bronidox is chemically the formal of 2-bromo-2-nitro-propane-l,3-diol (Bronopol) and therefore more stable than Bronopol. Figure 23 demonstrates that formaldehyde is released from Bronidox in a small amount only and very slowly even at pH 9. However, finally the degradation pathway follows the Bronopol pathway leading to formaldehyde, bromide, nitro-alcohols and nitrite. 

Dryce, D. M., Croshaw, D., Hall, J. E., Holland, V. R. Lessel, B. (1978). The activity and safety of the antimicrobial agent Bronopol (2-Bromo-2-nitro-propane-l,3-diol). /. Soc, Cosmet. Chem., 29, 3-24. 

In cosmetics, use of 5-bromo-5-nitro-l,3 dioxan (Bronidox) [II, 17.15.] and 2-bromo-2-nitro-propane-l,3-diol (Bronopol) [II, 17.14.] has declined dramatically, as there exists the risk that in cosmetic formulations containing amines N-nitroso compounds may originate which are known as carcinogens. 

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