BROMO-2-NAPHTHOL

In the reaction with 6-bromo-2-naphthol, no simple glycosides were obtained, but a mixture of tetracyclic compounds in yields of 32 % and 44 %, respectively (zirconocene activator). The hafnium reagent gave the same products in a similar ratio (21% and 44% yield) [30]. 

Bromo-2-naphthol has been prepared by the reduction of i,6-dibromo-2-naphthol with hydriodic acid,1 2 with tin and hydrochloric acid,3 or with stannous chloride and hydrochloric acid in aqueous alcohol3 or in aqueous acetic acid.4... 

This filtrate is stirred into 3 1. of cold water the 6-bromo-2-naphthol which is precipitated is filtered with suction, removed from the funnel, and washed by stirring with 1 1. of cold water. After filtering again and drying at ioo° there is obtained 214-223 g. (96-100 per cent of the theoretical amount) of 6-bromo-2-naphthol. This crude product, which is pink and melts at 123-127°, contains some tin but is pure enough for most purposes. 

A white product is obtained by vacuum distillation followed by crystallization of the crude product. Twenty-five grams of the crude substance on distillation (Note 3) gives 20 to 24 g. of distillate boiling at 200-205° at 20 mm., and when this is crystallized from a mixture of 75 cc. of acetic acid and 150 cc. of water it gives 17.5 to 22.5 g. of 6-bromo-2-naphthol which melts at 127-129°... 

More insight into the subcellular distribution of sialidases in intact cells is possible by histochemical means. For this purpose, 2-(5-bro-moindol-3-yl)-a-Neu5Ac and 2-(6-bromo-2-naphthyl)-a-Neu5Ac were synthesized, and the enzymieally liberated 5-bromoindole or 6-bromo-2-naphthol aglycon was spontaneously oxidized,189 or coupled to... 

In the presence of heptakis(6-bromo-6-deoxy-(3-CD) ((3-CD7Br), Femia and Cline Love observed the room-temperature phosphorescence of phenanthrene and other polynuclear aromatic hydrocarbons in N2-purged N,N-dimethylfol-mamide (DMF)-water mixtures [24], On the other hand, Hamai and Monobe observed room-temperature phosphorescence of 2-chloronaphthalene from a deaerated solution containing a 1 1 complex of 6-iodo-6-deoxy-(3-CD ((3-CDI) and 2-chloronaphthalene [25], This result indicates that even only one iodine atom on the (3-CD rim can accelerate the intersystem crossing rate of 2-chloronaphthalene included in the CD cavity. The room-temperature phosphorescence of 6-bromo-2-naphthol and 3-bromoquinoline was also observed for the complexes with (3-CDI [26],... 

Methods for the histochemical localization of /3-glucuronidase, employing the /3-glucuronides of 1-naphthol, 6-bromo-2-naphthol, l-(2-hydroxy-phenylazo)-2-naphthol, and 8-quinolinol as substrates, have been critically examined by Burton and Pearse.146 The last-named substrate gave the least unsatisfactory results, and the technique compares not unfavorably with histochemical methods for other enzymes. 

BROMO-2-NAPHTHOL, 20, 18 wi-Bromophenol, 23, 12 a-BROMO- 3-PHl NYLPROPIONIC ACID, 21,... 

Bromo-4-methoxytoluene, 26, 51 o-Bromo- -methylanisole, 23, 12 -Bromo-/3-m ethylvaleric acid, 21, 61 a-Bromonaphthalene, 21, 89 6-BROMO-2-NAPHTHOL, 20, 18 wt-Bromophenol, 23, 12 a-BROMO-/3-PHENYLPROPIONIC ACID, 21, 100... 

Bromo-2-naphthol [15231-91-1] M 223.1, m 122-126 , pKesi 9.1. Crystd from EtOH. 

Bromo-2-naphthol [15231-91-1] M 223.1, m 122-126", pKes, 9.1. Crystallise the naphthol from EtOH or C6H6/pet ether (m 128"). The benzoyl derivative has m 122", (from EtOH). [Ruggli Michels Helv Chim Acta 14 779 1931, Beilstein 6 H 651,6 II 605,6 III 2996.]... 

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