2-bromo-1 - ethanone

Furium. N[4-(5-Nitro-2-furanyl)-2-thia2olyl]acetamide, has demonstrated activity against baciUi and pathogenic enterobacteria (24). The product, prepared from thiourea and 2-bromo-l-(5-nitro-2-furanyl)ethanone followed by acetylation of the intermediate aminothia2ole with acetic anhydride in pyridine (25), is marketed in several countries for both human and veterinary use. 

Ethanone, 1- [3-(l,l-dimethylethyl)-4-methoxy-5-nitrophenyl Benzaldehyde, 2 (l,l-dimethylethyl)-4-methoxy-5-nitro Benzene, 1,4-BIS- (1, l-dimethylethyl)-2 methoxy-5-nitro Benzene, 1-(1, l-dimethylethyl)-2, 5-dimethoxy-4-nitro Benzene, 1-(1, l-dimethylethyl)-2-methoxy-4 methyl-5-nitro Benzaldehyde, 5- (1, l-dimethylethyl)-2-methyl-3-nitro Benzaldehyde, 2- (1, l-dimethylethyl)-4,5,6-trimethyl-3-nitro Benzene, 5-(l, l-dimethylethyl)-2-methoxy-l, 3-dinitro Benzene, 1-(1, l-dimethylethyl)-4-methoxy-2-methyl 3-5-dinitro Benzene, 2-bromo-5- (1, l-dimethylethyl)-4-methoxy-l,... 

Ethanone, 1 -[4( 1,1 -di methy le thy l)-2,3,6-tri methy l-5-nitropheny I ] Benzene, 1-(1, l-dimethylethyl)-3,5-dimethyl-2, 4,6-trinitro Benzene, l-bromo-3- (l,l-dimethylethyl)-5-methyl-2,4,... 

In the original patent published by Merck in 1995, rofecoxib (2) was synthesized in three steps from the known 4-(methylthio)acetophenone (10), prepared from the Friedel-Crafts acylation of thioanisole. As depicted in Scheme 2, oxidation of sulfide 10 using an excess of magnesium monoperoxyphthalate hexahydrate (MMPP, an inexpensive, safe and commercially available surrogate for w-CPBA) gave rise to sulfone 11, which was subsequently brominated with bromine and AICI3 to afford 2-bromo-l-(4-(methylsulfonyl)phenyl)ethanone (12). After recrystallization from 1 1 EtOAc/hexane, the pure phenylacyl bromide 12 was then cyclo-condensed with phenylacetic acid under the influence of l,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to deliver rofecoxib (2) in... 

C6H5BrOS 1 -(5-bromo-2-thienyl)ethanone 5370-25-2 25.00 1.6489 2 6836 C6H5N03 isonicotinic acid N-oxide 13602-12-5 53.33 1.3510 2... 

C8H6BrCIO 2-bromo-1-(4-chlorophenyl)ethanone 536-38-9 25.00 1.6070 2 1285C ) C8H6F202 3,5-difluorophenylacetic acid 105184-38-1 25.00 1.3010 2... 

C9H8CIFO 3-chloro-4 -fluoropropiophenone 347-93-3 25.00 1.2298 2 16251 C9H9BrO 2-bromo-1-(4-methylphenyl)ethanone 619-41-0 25.00 1.4298 2... 

Bromo-l-(4-nitrophenyl)ethanone oxime 222 was transformed into 3-hydroxy-4-(4-nitrophenyl)-2(3//)-thiazol-ethione 223 upon treatment with potassium ethyl xanthate and zinc chloride as shown in Scheme 88 <2004CL1274>. 

M-Bromo-p-chloroacetophenone oxime Ethanone, 2-bromo-1-(4-chlorophenyl)-oxime (12) (136978-96-6)... 

The McCoy method also allows the preparation of cyclopropylacylsilanes 33. Treatment of a-haloacylsilanes with lithium diisopropylamide (LDA) or with lithium tetramethylpiperidide (LUMP) affords enolates which combine with a variety of electrophilic olefins to produce cyclopropane derivatives33. The major diastereomers formed in the reactions of 2-chloro-l-(/er/-butyldimethylsilyl)ethanone are usually the civ-compounds, while the corresponding a-bromo acylsilane exhibits a higher degree of trans selectivity. 

Earlier, Kutterer et al. (05BMCL2527) (Scheme 80) reported that 4-methyl-1,2-fazs(4-chlorophenyl)pyrazolidine-3,5-dione 348 with 2-bromo-l-(2,4-difluoro-phenyl)ethanone 349 in toluene containing DIPEA under MW heating (900 W) for 1 min gave 4 -alkyl-4-methyl-pyrazolidine-3,5-dione 350 and 4-methyl-5-alkyloxy-pyrazol-3-one 351. Although compound 351 was evaluated as new inhibitor of bacterial cell wall biosynthesis, no separation and yields of 350 and 351 were reported. 

Bromo-2-(bromomethyl)pentanedi nitrile 2-Bromo-1-(4-bromophenyl)ethanone... 

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