Broccoli glutathione

LIN H J, PROBST-HENSCH N M, LOUIE A D, KAU I H, WITTE J S, INGLES S A, FRANKL H D, LEE E R and HAILE R w (1998) Glutathione transferase null genotype, broccoli and lower prevalence of colorectal adenomas . Cancer Epidemiol Biomarkers Prev, 7 647-52. 

The sulfur compound sulfuraphane, extracted from fresh broccoli, has received attention in recent years because of its strong action in inducing synthesis of quinone reductase and glutathione S-transferases that help detoxify xenobiotics and may have significant anticancer activity/... 

Similarly, it has been shown that consumption of cruciferous vegetables is associated with a lower incidence of cancers. Induction of phase II enzymes such as the glutathione S-transferase (GST) and quinone reductase (QR) have been demonstrated in broccoli, cabbage, and brussel sprouts. Many natural isothiocyanates derived from cruciferous vegetables and some fruits have been shown to cause induction of phase II enzymes in cultured cells and rodents. 

Erucht H, Engstrom PE. Prechnical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity. Chn Cancer Res 1997 3 25-30. 

Lin HI, Probst-Hensch NM, Louie AD, Kau IH, Witte JS, Ingles SA, Erankl HD, Lee ER, Haile RW. Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas. Cancer Epidemiol Biomark Pre 1998 7 647-652. 

McWalter GK, Higgins LG, McLeUan LI. et al. Transcription factor Nrf2 is essential for induction of NAD(P)H quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J Nutr... 

Gasper,A.V. etal. (2005)GlutathioneS-transferase Ml polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr 82 (6), 1283-1291... 

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