Broad bean pods

All foods diat may be spoiled Fava beans and broad bean pods Meat extracts (e.g., Bovril)... 

Tyramine acts as an indirect sympathomimetic to cause release of catecholamines from nerve terminals. It is present in a number of foods mature cheese, yeast extracts, some red wines, hung game, pickled herrings, broad bean pods. Normally, MAO-A in the intestinal mucosa will metabolise tyramine absorbed from the gut. In patients on the older MAOls, considerable amounts of tyramine will enter the circulation and this will lead to increased release of catecholamines stored in nerve terminals because the MAOI prevents their metabolism. For patients on RIMA drugs, high concentrations of tyramine can compete for MAO-A, thus mitigating some of the effects, and MAO-B is still available to metabolise noradrenaline (norepinephrine). MAO-B, however, has relatively much less effect on 5-HT and thus 5-HT function is still enhanced. 

Foods generally to avoid as they are usually high in tyramine content dry sausage, pickled herring, liver, broad bean pods, sauerkraut, cheese, yogurt, alcoholic beverages, nonalcoholic beer and wine, chocolate, caffeine, meat and fish... 

Buspirone Methyidopa Broad bean pods and Fava beans... 

A few reports describe a rapid, serious and potentially life-threatening hypertensive reaction in patients taking MAOIs if they eat young broad bean pods, which contain dopa. No serious hypertensive reaction is likely to occur with moclobemide. 

Although there are only a few cases of the interaction between the non-se-lective MAOIs (listed in Table 32.1 , (p.l 130)) and broad bean pods, the interaction would appear to be established and is serious and potentially life-threatening. Patients should not eat young broad bean pods during treatment with any of these MAOIs, nor for a period of 2 to 3 weeks after their withdrawal. It should be noted that this prohibition does not apply to mature broad beans (the seeds) removed from their pods, which is the more common way of eating broad beans. 

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