Breast cancer, treatment clinical trials role

Triptolide has been shown to induce apoptosis of several human cancer cell lines grown in culture and to inhibit tumor development in a murine breast cancer model " but has shown toxicity at high doses. The 14-succinyl sodium salt of triptolide (34), known as PG490-88, suppresses tumor growth without toxicity and has entered Phase I clinical trials the data is summarized as follows Our results suggest a potential role of PG490-88 alone and in combination with chemotherapy as a novel antineoplastic regimen for the treatment of patients with solid tumors. ... 

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