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Breast cancer drugs that cause

Testolactone is a synthetic drug related to testosterone. It is used for palliative treatment of advanced breast cancer in postmenopausal women and in women who have had their ovaries removed. The principal action of testolactone is reported to be inhibition of steroid aromatase activity and the reduction in estrone synthesis. The most common adverse effects are nausea, vomiting, and anorexia. An advantage is that it does not cause women to develop male characteristics such as a deep voice or facial hair. [Pg.459]

Tumors that are steroid hormone-sensitive may be either (1) hormone-responsive, where the tumor regresses following treatment with a specific hormone (2) hormone-dependent, where removal of a hormonal stimulus causes tumor regression or (3) both. Hormone treatment of responsive tumors is usually only palliative, except in the case of the cytotoxic effect of glucocorticoids (for example, prednisone) on lymphomas. Removal of hormonal stimuli from hormone-dependent tumors can be accomplished by surgery, for example, in the case of orchiectomy for patients with advanced prostate cancer, or by drugs, for example in the case of breast cancer, treatment with the antiestrogen... [Pg.403]

B. Bailey (1994), and Apricots and Oncogenes On Vegetables and Cancer Prevention by Eileen Jennings (1993). The latter emphasizes fohc acid and beta-carotene, and it is mentioned that fohc acid deficiency may be a major cause of colon cancer and breast cancer. It is relevant to mention here that carrots, a source of beta-carotene, are a folkloric anticancer agent, and also contain traces of bioactive alkaloids, for example, daucine, putrescine, and pyrrolidine, as well as other bioactive compounds. (Folate is commonly used as a carrier for the chanotherapy drug 5-FU, although the folate has anticancer action in itself.)... [Pg.121]


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