Branched, immunodominance

Many of the bacterial polysaccharides contain small, noncarbohydrate substituents that could be regarded as branches, and that can also be important in the serological reactions of polysaccharides. These substituents have been reviewed,1718 and the most important, in terms of the formulation of current, polysaccharide vaccines (see Section V,2), is the O-acetyl substituent. These substituents can be immunodominant, but are not exclusively so other populations of antibodies having specificities for other sectors of the polysaccharide are usually formed. 

B. Evidence for Immunodominant Groups in Synthetic Polypeptides with Branched Chains (Multichain Copolymers)... 

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