Brambell

Telleman, P, and R.P. Junghans, The role of the Brambell receptor (FcRB) in liver protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology, 2000.100(2) 245-51. 

Junghans, R.P, Finally The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol Res, 1997.16(1) 29-51. 

Holland, P.W., A.M. Hacker, and N.A. Williams, A molecular analysis of the phylogenetic affinities of Saccoglossus cambrensis Brambell Cole (Hemichordata). Philos Trans R Soc Lond B Biol Sci, 1991. 332(1264) 185-9. 

FcRn was originally known as the Brambell receptor, based on multiple studies conducted by F. W. Brambell involving maternal transmission of antibodies across placenta and neonatal intestine in rabbits [3,5,122,123], Transport was saturatable with increases in plasma IgG leading to reductions in plasma half-life (tm) according to the formula... 

Brambell FW, Hemmings WA, Morris IG. A theoretical model of gamma-globulin catabolism. Nature 1964 203 1352 1. 

Brambell FW, Flemmings WA, Oakley CL, Porter RR. The relative transmission of the fractions of papain hydrolyzed homologous gamma-globulin from the uterine cavity to the foetal circulation in the rabbit. Proc R Soc Lond B Biol Sci 1960 151 478-82. 

Brambell FW. The transmission of immune globulins from the mother to the foetal and newborn young. Proc Nutr Soc 1969 28( 1 ) 35—41. 

Brambell FWR, Hemmings WA, Morris LG. A Theoretical model of T -globulin catabolism. Nature 1964 1352-5. 

Hypo-IgG-globulinemia is also associated with myotonic dystrophy where the FOR can be 14% with a of 11 days (W12). This inborn error of IgG metabolism may be a loss of Brambell s protective intracellular carrier of IgG (B20) and some half of affected patients have subnormal serum levels of IgG. Rarely, similar endogenous hypercatabolism is found on a genetic basis and can affect several proteins (Rll). It is therefore clear that a subnormal serum level of IgG may be the result of increased catabolism or decreased synthesis. 

FIGURE 41.2 Clearance of antibodies is dependent on concentration. At low concentrations, therapeutic proteins may exhibit concentration-dependent clearance, with the clearance decreasing as concentrations increase. For most biological agents that display this behavior, the clearance will decrease to a particular level (the nadir in the curve) and then remain constant. However, for antibodies, a second form of saturation can occur, where the Brambell receptors become saturated, resulting in an apparent increase in clearance as concentrations increase. 

For large proteins, transfer across cell membranes is limited due to size and hydro-philicity of the molecule. There is some evidence that Brambell receptors may play a... 

Brambell F W, Hemmings W A, Morris I G (1964). A theoretical model of Gamma-Globulin Catabolism. Nature. 203 1352-1354. 

While postnatal transfer across the gut may be nonselective, as in ungulates (Halliday, 1965), prenatal transfer via the placenta and yolk sac is always specific for the IgG class of antibody (Brambel, 1970). The... 

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