Brain succinic dehydrogenase

BrouUlet E, Guyot MC, Mittoux V, Altairac S, Conde F, Palfl S, Hantraye P (1998) Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic add is suflflcient to initiate striatal degeneration in rat. J Neurochem 70 794—805... 

Increase in activity of cerebral succinic dehydrogenase and brain acid proteinase, and in brain RNA concentration decrease in liver cytochrome P-450 activity (22)... 

Mercury interferes with mitochondrial oxidation in the brain through mercaptide formation with thiol groups in pyruvate oxidase. Succinic dehydrogenase of the citric acid cycle is also inhibited. 

Both the membrane-bound and the soluble succinate dehydrogenases are capable of catalyzing fumarate reduction in the presence of a suitable electron donor such as FMNHa. In the mammalian enzyme, this activity is not more than a few percent of the succinate-PMS reductase activity (23, 25). Ringler and Singer (177) have also shown that in brain mito-... 

Koenig, H., Gaines, D., McDonald, T., Gray, R. and Scott, J. (1964) Studies of brain lysosomes. 1. Subcellular distribution of five acid hydrolases, succinate dehydrogenase and gangliosides in rat brain. J. Neurochem., 11, 729-743. 

Dragiev, M. and V. Ivanchev Changes in the activity of adenosinetriphosphatase and succinic dehydrogenase of the liver, kidneys, heart, and brain of rabbits under the effect of toxic substances forming during tobacco fermentation Gig. Tr. Prof. Zabo 15 (1971) 32-25. 

Valproic acid and its salts are a new group of antiepileptic drugs that differs from the known drugs both structurally and in terms of its mechanism of action. It is believed that it acts on the metabolism of the GABA system. Valproic acid has been shown to elevate the level of GABA in the brain by means of competitive inhibition of GABA transaminase and the dehydrogenase of succinic semialdehyde. 

MPP+ is a potent inhibitor of oxidation of the NAD+-linked substrates pyruvate/malate and glu-tamate/malate in isolated rat liver and brain mitochondria, while leaving the oxidation of succinate unaffected (Nicklas et al., 1985). The locus of inhibition of the mitochondrial respiration is assumed to be between the highest potential Fe-S cluster in NADH dehydrogenase and the coenzyme Q located probably at the rotenone-binding site (Ramsay et al., 1991). As a consequence of inhibition of respiration, cellular energy supplies in the form of ATP would rapidly be consumed, followed by depolarization of membranes, probable Ca influx and overstimulation of Ca +-dependent lysosomal enzymes. 

Succinic semialdehyde dehydrogenase (SSD) deficiency Brain, liver, kidney, lym- 6p22 phocytes, lymphoblasts, fibroblasts 271980... 

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