Brain slices intracellular studies using

The immediate and reversible actions of dopamine are a combination of modulations of individual ion channels. The major ion channels expressed in spiny projection neurons are summarized in Table 2. Current understanding of the properties of these channels is mostly based on whole cell recordings from isolated cells, which have been recently reviewed by Nichola et al. (2000). The role of these channels in whole cell behavior has been studied using intracellular recordings in brain slices or anaesthetized animals. Many of the important cellular properties of spiny projection neurons can be accounted for in terms of ion channel activations occurring at different membrane potentials. 

Law-Tho etal, (1994) studied the effects of dopamine on layer V pyramidal cells of the prefrontal cortex using intracellular recording in rat brain slices. Their findings indicate that DA decreases both glutamatergic and gabaergic synaptic transmission in neurons located in layer V of rat prefrontal cortex,... 

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