Brain malic” enzyme

McKenna, M. C., Tildon, J. T., Stevenson, J. H., Huang, X. and Couto, R. Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes. Neurochem. Res. 20 1491-1501 1995. 

A diet high in carbohydrates also stimulates malic enzyme activity and synthesis in rodent and avian liver while starvation or low carbohydrates has the opposite effect [67,74]. Recent data demonstrated [75] that a high-carbohydrate diet increases the cytoplasmic malic enzyme mRNA at a post-transcriptional level probably by retarding its degradation. Such a control is liver specific since no response was observed in brain, heart, kidney and other non-hepatic tissues. The amplitude of the response to the high carbohydrate diet is increased several fold by T3. 

Kurz GM, Wiesinger H, Hamprecht B (1993) Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures, y Neurochem 60 1467-1474. 

Vogel R, Jennemann G, Seitz J, Wiesinger H, Hamprecht B (1998) Mitochondrial malic enzyme purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain. J Neurochem 77 844-852. 

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