Brain glycoprotein synthesis

The enzyme catalyzing reaction 6 was also found in the brain of young rats. In addition to lactosylceramide, lactose was also claimed to serve as a substrate. Care is, however, needed in interpreting these results, because chick brain is known to contain a fourth sialyl transferase that utilizes various jS-D-galactosides as acceptors, and which is, presumably, involved in glycoprotein synthesis. ... 

Synthetic glycoproteins allow varied approaches to be tested. Davis et al. described the synthesis of glycoprotein probes able to detect mammalian brain inflammation and disease by using a dual tag approach [118]. They established two different orthogonal modifications in a selected protein (Scheme 19.11) [118, 119]. These modifications were introduced by disulfide formation at a single Cys position and by... 

Inhibin (IHB), a glycoprotein which is secreted by the gonads and inhibits FS H production and release. Other sites of synthesis are the brain and placenta (in humans). IHB-A and IHB-B are heterodimers which are linked together by disulfide bonds. The a-chains are identical, and structural similarities exist between the a- and /S-chains [N. Ung et al., Endocr. Rev. 1988, 9, 267 J. 

J. Tan, J. Dunn, J. Jaeken, H. Schachter, Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development. Am J Hum Genet, 1996, 59, 810-817. 

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