Brain enriched

Specific Alterations in the Expression of Brain-Enriched Genes. 810... 

Massa PT (1993) Specific suppression of major histocompatibility complex class I and class II genes in astrocytes by brain-enriched gangliosides. J Exp Med 178 1357-1363. 

Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K et al. (1998) BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. J Biol Chem 273 26269-26272. 

Diering GH, Mills F, Bamji SX, Numata M. Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na(+)/H(+) exchanger NHE5. Mol Biol Cell. 2011 22(13) 2246-2257. 

Jussofie A, Schmiz A, Hiemke C. Kavapyrone enriched extract from Piper methys-ticum as modulator of the GABA binding site in different regions of rat brain. Psychopharmacology (Berl) 1994 116 469-474. 

Walaas, S.I., Aswad, D.W., Greengard, P. A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature. 301 69, 1983. 

Central nervous system myelin is enriched in certain lipids. Table 4-1 lists the composition of bovine, rat, and human myelin compared to bovine and human white matter, human gray matter, and rat whole brain [1] (see Ch. 3). While there are no absolutely myelin-specific lipids, cerebroside (galactosyl ceramide) is the most typical of myelin. With the exception of early development,... 

The activity of G protein Py subunits is modulated by another protein termed phosducin [16]. Phosducin is a cytosolic protein enriched in retina and pineal gland but also expressed in brain and other tissues. Phosducin binds to G protein Py subunits with high affinity. The result is prevention of Py subunit reassociation with the a subunit. In this way, phosducin may sequester Py subunits, which initially may prolong the biological activity of the a subunit. However, eventually this sequestration may inhibit G protein activity by preventing the direct biological... 

There exists an unusual uniformity in the fatty acid composition of the inositol lipids. All three of the major phosphoinositides are enriched in the 1-stearoyl, 2-arachidonoyl ( ST/AR ) sn-glycerol species (=80% in brain). The polyphosphoinositides (PI4P and PI(4,5)P2) are present in much lower amounts than PI. PI(4,5)P2 has been shown to be predominantly, although not... 

---