Brain 5,7-dihydroxytryptamine

Toxins that gain access to a neuron through its uptake process and then destroy it in some way. This approach has been used mainly to destroy monoamine neurons with 5,6 or 5,7-dihydroxytryptamine targeting 5-HT neurons, 6-hydroxydopamine for dopamine (and to a lesser extent noradrenergic) neurons and MPTP for dopamine neurons (see Chapter 7). Only the latter is fully specific and effective systemically. The others need to be administered directly into the appropriate brain areas and while they may only affect the intended NT neurons, the injection may not affect all of them. 

Bjorklund, A Nobin, A and Steveni, U. Regeneration of central serotonin neurons after axonal degeneration induced by 5,6-dihydroxytryptamine. Brain Res 50 214-220, 1973. 

Baumgarten, H.G. Lachenmayer, L. and Schlossberger, H.G. Evidence for a degeneration of indolamine-containing nerve terminals in rat brain, induced by 5,6-dihydroxytryptamine. Z Zellforsch 125 553-569, 1972. 

Wiklund, L., and Bjorklund, A. Mechanisms of regrowth in the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy. 11. Fluorescence histochemical observations. Brain Res 191 129-160. 1980. 

Commins, D.L. Axt, K.J. Vosmer, G. and Seiden, L.S. Endogenously produced 5,6-dihydroxytryptamine may mediate the neurotoxic effects of para-chloroamphetamine. Brain Res 419 253-261, 1987. 

Leccese, A.R, Lyness, W.H. The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. Brain Res. 303 153, 1984. 

Hole, K., Fuxe, K., and Jonsson, G. (1976) Behavioral effects of 5,7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways. Brain Res., 107 385-399. 

Warbritton, J. D., Ill, Stewart, R. M., and Baldessarini, R. J. (1980) Increased sensitivity to intracerebroventricular infusion of serotonin and deaminated indoles after lesioning rat with dihydroxytryptamine. Brain Res., 183 355-366. 

Verge D, Daval G, Marcinkiewicz M, et al. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J Neurosci 1986 6 3474-3482. 

Fischette CT, Nock B, Renner K. Effects of 5,7-dihydroxytryptamine on sero-toninl and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res 1987 421 263-279. 

Injection of 5,6-dihydroxytryptamine (5,6-DHT) in laboratory rats, produces profound reduction of tryptophan hydroxylase in the brain and spinal cord. A week following the injection hydroxylase activity returns to normal in most of the brain, but not in the spinal cord. 

Injection of 5,7-dihydroxytryptamine in the rat induced a reduction of tryptophan hydroxylase in all regions of the brain. It also caused depletion of norepinephrine, but did not deplete dopamine. The pretreatment of laboratory animals with desmethylimipramine (desipramine) blocked the neurotoxic reaction to the norepinephrine reuptake system, but did not protect the serotonergic reuptake system. (Lovenburg 1978). 

Lehmann O, Jeltsch H, Lehnardt O, Pain L, Lazarus C, Cassel JC. Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG-saporin and 5,7-dihydroxytryptamine neurochemical and behavioural characterization. Eur J Neurosci 2000 12 67-79. 

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