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Brain CarbE

The CarbE profile in humans is not well known. While CarbEs were considered to be absent from the blood plasma of humans (Li et al, 2005), they are, indeed, present in human erythrocytes and monocytes as well as in human liver, kidney, lung, skin, and nasal tissue (Cashman et al, 1996). Additional literature documents the presence of CarbEs in many human tissues and fluids, including brain, milk, mammary gland, pancreas, small intestine, colon. [Pg.804]

The essential fatty acids are also converted in the body to the 22-carbon fatty acids docosapentaenoic acid (DPA)and docosahexaenoic acid (DHA). DPAis made from linoleic acid DHA is made from linolenic acid.The functions of these 22-carb-on fatty acids are not clear, but they may be important for vision and for other functions of the nervous system. DPA and DHA can be further elongated, in the body, to the "very-long-chain fatty acids." The very-long-chain fatty adds contain 24 to 34 carbons, and occur in the brain, rods of the retina, and in the testes (Sixh et al., 1996). Their functions are not clear. [Pg.638]

The activities of CarbEs have been localized and determined in almost all tissues, with the highest activity in liver. A substantial amount of the enzyme activity is present in heart, kidney, lungs, brain, skeletal muscles, testes, small intestine, pancreas, nasal mucosa, adipose tissue, and plasma. Normal values of CarbEs for some of the tissues, using tributyrin as the substrate, are given in Table 1. No significant variability in the... [Pg.432]

Toxicity of organophosphates can be potentiated 15-20-fold in rats and mice by pretreatment with a metabolite of tri-O-cresylphosphate, CBDP (2-0-cresyl)-4H-l,3,2-benzodioxa-phosphorin-2-oxide), which is an irreversible inhibitor of CarbEs. In similar studies, tetraisopropylpyrophosphoramide (iso-OMPA), or mipafox, an organophosphate-irreversible inhibitor of CarbEs, potentiates three-to fivefold the toxicity of several OPs (soman, DFP, and methylparathion) and carbamates (carbofuran, aldicarb, propoxur, and carbaryl). Inhibition of CarbEs by CBDP, iso-OMPA, or mipafox pretreatment, particularly in plasma, liver, heart, brain, and skeletal muscles, is a major contributory factor in the potentiation of toxicity of organophosphates and carbamates. Thus, the toxicity of any drug, pesticide, or other type of agent that is normally detoxified by CarbEs, could be potentiated by pre-exposure to an organophosphorus or other carboxylesterase inhibitor. [Pg.434]

Glucose is the body s preferred energy substrate. Though the brain s nutrient make-up is nearly 1/3 omega-3 fatty acids it is glucose that is without fail mandatory for continued sentience. So carb up a little and read closely as we learn a few things about the body we have been entrusted to play nice with. [Pg.127]

Although by now even fast-food addicts have the guilty sense that french fries and pizza aren t exactly good for our health, very few of us realize that these poor food choices are also disastrous for our mood. Too many refined carbs and unhealthy fats play havoc with our brain chemistry as well as our weight, working against our efforts to overcome depression no matter how much medication we take. [Pg.3]

FAST FOOD FOR THE BRAIN COMPLEX VS. REFINED CARBS... [Pg.51]

You can see why complex carbs are so much better for your moods. They re also better for your brain, which much prefers to get a relatively constant supply of glucose. So switching from refined to complex carbs will immediately help you to feel calmer, fuller, and more in control of your appetite—especially if you re sugar-sensitive. [Pg.52]

You should eat to boost your serotonin levels, as described above—but with one modification. Given the excessive amounts of dopamine and/or norepinephrine in your brain, you would do well to eat very small amounts of protein, at least until things calm down. Get plenty of healthy carbs and essential fatty acids into your diet, and avoid highly concentrated protein sources, especially meat and seafood. In fact. I d suggest a good old-fashioned vegetarian diet, in which you eat a combination of beans and whole grains as your protein source, at least until you recover. [Pg.63]

The brain uses serotonin molecules to make melatonin. So if increased darkness leads to a rise in melatonin production, your serotonin levels are likely to suffer. At the same time, a lack of exercise, an overconsumption of refined carbs, sweets, and comfort foods, and excessive sleep may have contributed to a dopamine/norepinephrine deficiency. So typically, people with SAD experience both the carbohydrate cravings associated with low serotonin levels and the weight gain, stress sensitivity, and sluggishness that accompany norepi/dopa shortages. [Pg.110]

To develop a PD model for cholinesterase-inhibiting compounds, the steady-state levels (p,mol) of B-esterase enzymes (AChE, BuChE. and CarbE) were determined for the variou.s tissues (c.g., brain, blood, liver, and diaphragm) based on the rates of enzyme synthesis (zero-order) and degradation (first-order) (Gearhart et al., 1990). The... [Pg.111]

These estimates were then utilized for both the rat and the human dynamic models (Timchalk et al., 2002b). It is important to note that since the PD model is highly dependent on the estimates of these enzyme levels, additional experimental measurements, particularly in humans, may be warranted (Knaak et al., 2004). The enzyme degradation rates for AChE, BuChE, and CarbE were initially based on the first-order loss of rat brain AChE (Wenthold et al... 1974) as described by Gearhart et al. (1990). As a first... [Pg.112]

A scavenger function of rodent plasma CarbE able to prevent the highly toxic ChE inhibitors from reaching the AChE in the brain and diaphragm depends on the fact that CarbE, which is a B-esterase (Aldridge, 1953 Jansz et ai, 1959 Aldridge and Reiner, 1972), is able to bind and thereby detoxify the ChE inhibitors at the active site... [Pg.261]

Py r roline - 5 - carb oxylate (P5CDH) dehydrogenase deficiency (Hyperprolinemia type 2) Liver, kidney, brain, leukocytes, fibroblasts 239510... [Pg.126]

Carbohydrates, made up of starches, sugars, and fiber, provide us with the fuel we burn daily. Without them, our bodies can feel sluggish and our brains fuzzy. The higher the fiber and the lower the sugar, the better the carb. [Pg.49]


See other pages where Brain CarbE is mentioned: [Pg.77]    [Pg.120]    [Pg.77]    [Pg.120]    [Pg.122]    [Pg.51]    [Pg.768]    [Pg.803]    [Pg.804]    [Pg.805]    [Pg.1035]    [Pg.1036]    [Pg.284]    [Pg.433]    [Pg.258]    [Pg.262]    [Pg.51]    [Pg.53]    [Pg.61]    [Pg.138]    [Pg.106]    [Pg.113]    [Pg.261]    [Pg.263]    [Pg.612]    [Pg.448]    [Pg.811]    [Pg.345]    [Pg.98]    [Pg.831]    [Pg.889]    [Pg.890]    [Pg.1101]    [Pg.1103]   
See also in sourсe #XX -- [ Pg.120 ]




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