Botulinum toxins Aminoglycosides

The effect of administering different botulinum neurotoxin serotypes at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin. Aminoglycosides Cautiously perform coadministration of botulinum toxin type A and aminoglycosides or other agents interfering with neuromuscular transmission (eg, curare-like nondepolarizing blockers, lincosamides, polymyxins, quinidine, magnesium sulfate, anticholinesterases, succinylcholine chloride) because the effect of the toxin may be potentiated. 

Santos, J.l., Swensen, P., and Glasgow, L.A. 1981. Potentiation of Clostridium botulinum toxin aminoglycoside antibiotics chnical and laboratory observations. Pediatrics 68 50-54. 

Clindamycin, aminoglycosides, and succinylcholine may potentiate neuromuscular effects of botulinum toxin... 

Theoretically, the neuromuscular blocking effects of botulinum toxin can be increased by other drugs with neuromuscular blocking effects, such as the aminoglycosides and muscle relaxants, but no such interactions have been reported. 

Molgo J, Lemeignan M, Thesleff S (1987) Aminoglycosides and 3,4-diamino-pyridine on neuromuscular block caused by botulinum type A toxin. Muscle Nerve. 10 464-70. 

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