Bornyl diphosphate

This enzyme [EC 5.5.1.8], also known as geranyl-diphos-phate cyclase, catalyzes the conversion of geranyl diphosphate to (-r)-bornyl diphosphate. 

Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998) Monoterpene synthases from common sage (Salvia-ojficinalis) cDNA isolation, characterization and functional expression of (-l-)-sabinene synthase, 1,8-cineole synthase, and (-l-)-bornyl diphosphate synthase. /. Biol. Chem., 273,14891-9. 

More than a dozen cDNAs encoding monoterpene synthases from a range of plant sources have now been isolated [22, 32-36]. The corresponding recombinant enzymes generate a diverse set of products and provide an exceptional set of catalysts for the detailed study of structure-function relationships in monoterpene cyclization. However, it was earher work with native synthases that first allowed definition of the cyclization reaction [ 15]. Thus, the stereochemical model for monoterpene cyclization was developed largely from studies with the bicyclic monoterpene cyclases (-i-)- and (-)-bornyl diphosphate synthases, (-1-)-and (-)-pinene synthases, and (-)-e do-fenchol synthase. It was also the purification of several native monoterpene synthases that gave the first indication that... 

BORNYL PYROPHOSPHATE SYNTHASE Geranyl diphosphate synthase,... 

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