Bone marrow depression phenylbutazone

Chaplin S. Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol—Part II. Adverse Drug React Acute Poisoning Rev 1986 5(3) 181-96. 

Specific anti-platelet antibodies can cause thrombocytopenic purpura (18), which can be fatal. The increased risk of leukemia after phenylbutazone could be secondary to bone marrow depression (SED-9,143) (19). 

Acute intoxication with phenylbutazone is dominated by metabolic acidosis, which can progress to coma, seizures, hypotension, shock, and oliguria. Kidney and liver reactions, acute bone marrow depression, and acute perforation of peptic ulcer have all been described (5,11,35). 

Inman WH. Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone. BMJ 1977 l(6075) 1500-5. 

Two patients taking methotrexate for psoriasis developed methotrexate toxicity and skin ulceration shortly after starting to take phenylbutazone 200 to 600 mg daily. One of them died from septicaemia following bone marrow depression. ... 

Bone marrow depression and agranulocytosis have been observed after therapeutic doses of colchicine (202, 203 ). Fatal bone marrow depression occurred in a 70-year-old man with gout shortly after operation for perforation of a gastric ulcer associated with administration of phenylbutazone. He had been given 12 mg of colchicine intravenously over a period of 5 days (202 ). Acute myelomonocytic leukaemia and multiple myeloma occurred in 3 of 25 patients with gout given sulphinpyrazone and colchicine. Colchicine was taken intermittently and for shorter periods than the sulphinpyrazone (204 ). 

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