Bone/biomaterial interfaces

Meunier, A., Katz, J. L., Christel, P., and Sedel, L. (1988). A reflection scanning acoustic microscope for bone and bone-biomaterials interface studies. /. Orthopaedic Res. 6, 770-5. [197]... 

Brunski, X B., Influence of biomechanical factors at the bone-biomaterial interface, in The Bone-Biomaterial Interface (X E. Davies, Ed.),pp. 391-404, University of Toronto Press, Toronto, 1991. 

Kasemo, B. and Lausmaa, J. (1991) in The Bone-Biomaterials Interface (ed. J.E. Davies), University of Toronto Press, pp. 19-32. 

As discussed in detail in Chapter 3.1, the advantage of bioinert materials is that they do not release any toxic constituents to the human body environment. However, on the downside they do not show positive interaction with living tissue. Instead, the body usually responds to these materials by forming a non-adherent fibrous capsule of connective tissue around the bioinert material that in the case of bone remodelling manifests itself by a shape-mediated contact osteogenesis. Consequently only compressive forces will be transmitted through the bone-biomaterial interfaces ( bony on-growth ). 

Tarasevich, B.J. Rieke, P. C. McVay, G. L. In The Bone-Biomaterial Interface Univ. of Toronto Press, Toronto, 1991, in press. 

BON 91] BONFIELD W. and LUBLINSKA Z.B., High resolution microscopy of lx)ne implant surface . The Bone-Biomaterial Interface, ed. J.E. Davies, Toronto University Press, 1991. 

Composites provide an atPactive alternative to the various metal-, polymer- and ceramic-based biomaterials, which all have some mismatch with natural bone properties. A comparison of modulus and fracture toughness values for natural bone provide a basis for the approximate mechanical compatibility required for arUficial bone in an exact structural replacement, or to stabilize a bone-implant interface. A precise matching requires a comparison of all the elastic stiffness coefficients (see the generalized Hooke s Law in Section 5.4.3.1). From Table 5.15 it can be seen that a possible approach to the development of a mechanically compatible artificial bone material... 

Biomaterial scientists and engineers are currently investigating novel formulations and modifications of existing materials that elicit specific, timely, and desirable responses from surrounding cells and tissues to support the osseointegration of the next generation of orthopedic and dental biomaterials (Ratner, 1992). Enhanced deposition of mineralized matrix at the bone-implant interface provides crucial mechanical stability to implants. Proactive orthopedic and dental biomaterials could consist of novel formulations that selectively enhance osteoblast function (such as adhesion, proliferation and formation of calcium-containing mineral) while, at the same time, minimize other cell (such as fibroblast) functions that may decrease implant efficacy (e.g., fibroblast participation in callus formation and fibrous encapsulation of implants in vivo). 

Dee, K. G, Andersen, T. T., Rueger, D. G, and Bizios, R., Conditions which promote mineralization at the bone/implant interface a model in vitro study. Biomaterials 17, 209-215... 

The aim of this paper is to present the use of a microwave digestor to prepare nanopowders via hydrothermal route. In the field of biomaterials the researchers (due to some problems with the traditional materials) are looking for the design of biomaterials with surface properties similar to physiological bone (grain sizes in the nanometric range [5]). This would aid in the formation of new bone at the tissue/biomaterial interface and therefore improve implant efficacy. With the advent of nanostructured materials (materials with grains sizes less than 100 nm in at least... 

Puleo DA, Nanci A (1999) Understanding and controlling the bone-implant interface. Biomaterials 20(23-24) 2311-2321... 

Rozema, F.R. dc Bruijn, W.C., Bos, R.R.M., Boering, G., Nijenhuis, A.J., Pennings, A.J. (1992) Late Tissue response to bone-plates and screw s of poly(l-lactide) used for fracture fixation of the zygomatic bone, biomaterial-tissue interfaces. In PJ. Dougherty, et al. (eds). Advances in Biomaterials, 10, 349-335. 

Davies JE, T ami E, Moineddin R, Mendes VC. The roles of different scale ranges of surface implant topography on the stability of the bone/implant interface. Biomaterials... 

Davies JE, Mendes VC, Ko JCH, Ajami E. Topographic scale-range synergy at the functional bone/implant interface. Biomaterials 2014 35 25-35. 

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