Body weight, set point

Fantino M, Fafon F, Roland Y (1986) Effect of dexfenfluramine on body weight set-point Study in the rat with hoarding behavior. Appetite 7 (Suppl) 115-126... 

Evidence consistent with the idea of a body-weight set point is observed in animals with normal body weight as well. For example, like others (Keesey Hirvonen, 1997),... 

Keesey RE, Hirvonen MD. Body weight set-points determination and adjustment. J Nutr 1997 127 1875S-1883S. Keesey RE, Mitchel JS, Kemnitz JW. Body weight and body composition of male rats following hypotha-... 

The lipostat theory postulates a mechanism that inhibits eating behavior and increases energy consumption whenever body weight exceeds a certain value (the set point) the inhibition is relieved when body weight drops below the set point (Fig. 23-30). This theory predicts that a feedback signal originating in adipose tissue influences the brain centers that control eating behavior and activity (metabolic and motor). The first such factor, leptin, was discovered in 1994, and several others are now known. 

Another point with respect to graphical display of covariate relations concerns interactions between covariates, that is, when the relation between the parameter and covariate depends on the value of another covariate. For example, if males and females have different relations between clearance and body weight. Given that the data set contains enough individuals to support the identification of interaction... 

Mrosovsky N, Powley TL. Set points for body weight and fat. Behav Biol 1977 20 205-223. 

The methods which have been presented to this point are used in the evaluation of one or more samples. In many instances, however, one wishes to evaluate the relationship between two or more variables. The relationship between dose of a drug in the diet and body weight of mice, the plasma levels of a drug as a function of time or a comparison of a new analytical method compares to a standard method are examples of such problems. In this section, discussion will focus on the case of two variables X and Y. It will be initially assumed that the variable X (the independent variable) is measured with little or no error and is set prior to the time when the experiment is conducted. The second variable, Y, (the dependent variable) is the response variable which is dependent on the value of X. Y is measured with error. The evaluation of the relationship between X and Y... 

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