Blues acetamidate

The original blue (K.A. Hofmann, 1908) was obtained from the reaction of Pt(MeCN)2Cl2 with silver salts over some hours. Under these conditions, the nitrite is hydrolysed to acetamide. Very recently, the structure of the complex [(H3N)2Pt(MeCONH)2Pt(NH3)2]4(NO3)10 has been determined (Figure 3.37). The average oxidation state of the platinums in the octamer is 2.25. 

We like to conclude the section with the spectacular molecular structure of the octanuclear platinum acetamidate blue [Pt8(NH3)16 (CH3CONH)8]10+, Figure 2, even if no pertinent electrochemical investigation has been carried out.25... 

There has been considerable interest in hydroxy-3,3 -bipyridines and 3,3 -bipyridinones. Following from some very early work on the oxidation of citrazinic acid (2,6-dihydroxypyridine-4-carboxylic acid), which was considered to give some polyhydroxy-3,3 -bipyridines, it has been shown that the 3,3 -bipyridinone 59, a product of the hydrolysis of a natural blue pigment from Corynehacterium insidiosum, is obtained by oxidation of 2-hydroxy-5-aminopyridine (60) or 2,6-dihydroxypyridine-4-carboxylic acid 61) 80,83 similar oxidation of 2,6-dihydroxy-3-aminopyridine-4-carboxylic acid affords the natural product indigoidine (20). Numerous related oxidative condensations have been reported subsequently. Cyano-acetamide condensations analogous to those discussed in the synthesis of 2,3 -bipyridines afford, for example, the cyano-substituted 3,3 -bipyridinone 62 588 v, lereas condensation of 3-pyridylacetonitrile with ethyl phenyl-propiolate and ethanol affords compound 63. To complete the section on... 

PtCl2(py)DMF] is in equilibrium with [Pt2Cl4py2] and free DMF.51 The platinum blue product from the reaction of K2[PtCl4] with acetamide now appears to contain some Ptm and to have MeCONH- groups and not neutral acetamide.52... 

Oxidation, reagents Barium permanganate. Bismuth trIoxide. Blue tetrazolium. N-Bromo-acetamide. Bromocarbamide. N-Bromoiucclnlmldc. l-Butyl chromate. r-Butyl hypochlorite. r-Butylhydroperoxide. Caro i. acid. Ceric ammonium nitrate. o-Chloranll. m-Chloropei benzoic acid. NChloroauccinlmlde. Chromic Mid In dll. HiSOi, in acetone (Jonee reagent)i... 

It has been reported that cz5-dichlorodiammineplatinum(II) reacts with acetamide, yielding dichroic blue needle crystals of variable composition which presumably have extensive metal-metal interactions (157). Other properties of this complex have not been reported. 

Ammonium citrate tribasic Ammonium fluoborate Ammonium-12-molybdosilicate Ammonium phosphomolybdate Basic blue 9 Bromodichloromethane t-ButyIdimethylsilyl imidazole Chromium chloride (ous) Dimethyl acetamide Dimethyl formamide Ethoxydiglycol acetate Ethyl acetate Ethylbenzene Ethyl formate Ferric sulfate Formic acid Heptane Hexamethylenetetramine Isopropyl ether Methyl cyclohexane 2,7-Naphthalenediol ... 

Since aU steps of the three-component sequence are conducted under microwave irradiation, the tide compounds can be rapidly obtained (within a total reaction time of 90 min) in mostly moderate yields. As a general trend p-chlorophenyl-substituted N-(prop-2-yn-lyl) acetamide furnishes higher average yields in comparison to the p-tolyl-substituted analogs, which was attributed to the cycloisomerization step of the sequence, where the deprotonarion of the propargyHc position essentially terminates the oxazole formation. Interestingly, the aryl substituted 5-(3-indolyl)oxazoles 43 display intense blue fluorescence and large Stokes shifts upon UV-irradiation both in solution and in the soHd state. 

Other Names L 7545 Lyso Sensor DND 160 LysoSensor Yellow/Blue DND 160 PDMPO CA Index Name Acetamide, N-[2-(dimethylamino)ethyl]-2-[4-[5-(4-pyridinyl)-2-oxazolyl]phenoxy]-CAS Registry Number 231632-18-1 Merck Index Number Not listed Chemical Structure... 

On the other hand, the 6>-protonated acetamide cationhas some blue as well as greenmapped to both its NH2 group and O—H (protonated carbonyl) group, suggesting delocalization of the positive charge between these two locations. 

Platinum-acetamide-blue and platinum-uracil-blue compounds have been reported. The tetranuclear uracil blue [Pt4(l-MeU)4(NH3)g](N03)5-H20, where 1-MeU is the mono-anion of 1-methyluracil, has structure and properties resembling 2-pyridone-blues. Platinum blue compounds with uridine, isonicotinamide, malonamide, and biuret have been described. ... 

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