Blood products and therapeutic enzymes

Blood and blood products constitute a major group of traditional biologies. The main components of blood are the red and white blood eells, along with platelets and the plasma in which these eellular elements are suspended. Whole blood remains in routine therapeutic use, as do red blood cell and platelet coneentrates. A variety of therapeutieally important blood proteins also eontinue to be purified from plasma. These inelude various elotting faetors and immunoglobulins (immunoglobulins will be considered in the next ehapter). Sueh blood produets are summarized in Table 9.1. [Pg.351]

Associated with the administration of blood or blood products is the risk of aeeidental transmission of infectious agents. Transmission of hepatitis, as well as AIDS, has generated prominent attention in this regard, but several bacterial and parasitic diseases may also be transmitted via infected blood products (Table 9.2). [Pg.351]

Rigorous application of good manufacturing practice (GMP) with regard to the manufacture of blood products is required to minimize the risk of pathogen transmission. Most GMP or related guidelines contain sections that address issues particularly relevant to the production of blood products. The prevention of accidental pathogen transmission relies upon [Pg.351]

The identity of each blood donor should be recorded, and all donor blood bags must be labelled carefully. Traceability of individual blood donors/donations is essential, in case the donor or product is subsequently found to harbour blood-borne pathogens. The risk of contamination of blood during collection/processing is minimized by using closed systems and strict aseptic technique. [Pg.351]

Biopharmaceuticals Biochemistry and Biotechnology, Second Edition by Gary Walsh John Wiley Sons Ltd ISBN 0 470 84326 8 (ppc), ISBN 0 470 84327 6 (pbk) [Pg.351]

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