Blood pressure lowering secondary prevention

Blood pressure lowering is effective in both the primary and secondary prevention of both ischemic and hemorrhagic stroke regardless of blood pressure. 

The FDA has approved the use of 325 mg/d for primary prophylaxis of myocardial infarction but urges caution in this use of aspirin by the general population except when prescribed as an adjunct to risk factor management by smoking cessation and lowering of blood cholesterol and blood pressure. Meta-analysis of many published trials of aspirin and other antiplatelet agents confirms the value of this intervention in the secondary prevention of vascular events among patients with a history of vascular events. 

The roles of EPA and DHA in cells include the regulation of eicosanoid production from arachidonic acid (AA 20 4n-6), in that EPA competes with AA to produce various eicosanoids such as the 3-series prostaglandins, prostacyclin, and thromboxane, and the 5-series leukotrienes (LT) and lipoxins. EPA and DHA lower plasma TAG levels and blood pressure (De Deckere et al, 1998 Mori etal, 1999) and regulate ion flux in cardiac cells (Kang and Leaf, 2000). There have been successful trials of secondary prevention of myocardial... 

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