Blood levels factors affecting

The answer is e. (Hardman, p 21J The fraction of a drug dose absorbed after oral administration is affected by a wide variety of factors that can strongly influence the peak blood levels and the time to peak blood concentration. The Vd and the total body clearance (Vd x first-order fte) also are important in determining the amount of drug that reaches the target tissue. Only the area under the blood concentration-time curve, however, reflects absorption, distribution, metabolism, and excretion factors it is the most reliable and popular method of evaluating bioavailability... 

He Y, Miao M, Herrinton LJ, Wu C, Yuan W, Zhou Z, Li DK (2009) Bisphenol A levels in blood and urine in a Chinese population and the personal factores affecting the levels. Environ Res 109 629-633... 

C. The dietary intake of purines is not a major contributing factor to uric acid blood levels. Therefore, pharmacological reduction of uric acid synthesis or increased excretion is required. Dietary restriction (A) can affect uric acid production if precursor molecules are lowered sufficiently, but this usually is not feasible. The question of drug specificity (B) is not germane to the question. Pathways of uric acid synthesis in the body (D) are well known. 

Gamble, M.V. and W.S. Blaner. Factors affecting blood levels of vitamin A. In Vitamin A and Retinoids An Update of Biological Aspects and Clinical Applications, edited by M.A. Livrea, Boston, Birkhauser Verlag, pp. 1-16, 2000. 

It is important to note that the SUV values are affected by several factors. The time period between tracer injection and scanning (i.e., the uptake period) is perhaps the largest single source of error in determining the SUV. Time to reach maximum uptake in a given tissue varies with the type and condition of tissue, i.e., different forms of neoplasm and also with tissues before and after therapy. Tissue uptake of FDG decreases with increasing blood glucose level, which affects the SUV. Excess body fat falsely elevates... 

Factors Affecting Blood Levels of Ascorbic Acid and Glutathione. 71... 

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