Blood glucose response studies

In contrast, in a very similar study by the same research group, the combination of gemfibrozil and itraconazole caused only a modest 47% increase in the AUC of a single dose of nateglinide 30 mg, and did not significantly alter the blood glucose response to nateglinide in healthy subjects. ... 

Some clinical trials can be completed with only a few visits. Others require more frequent contact with the study staff. As an example of the former, our clinic has conducted many studies intended to assess blood insulin and glucose responses to test products such as snack bars and beverages. These are usually conducted using a cross-over design and may require only three visits one for screening, one for consumption of the control product, and one for consumption of the active product. In contrast, we have also completed several trials to assess dietary and pharmaceutical interventions intended to promote weight loss. These usually require frequent clinic visits over a period of at least 12 weeks and sometimes as long as two years. 

Glucose concentrations have been studied in 47 patients with non-responsive schizophrenia taking olanzapine (872). Three of them, who had taken olanzapine for 3-6 months, had persistently high blood glucose concentrations. However, this is similar to what would be expected on the basis of the prevalence of diabetes mellitus in US adults. 

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