Blood gases neonatal

Kolinski B, Kuster H, Ugele B, Gruber R, Horn K. Total bilirubin measurement by photometry on a blood gas analyzer potential for use in neonatal testing at the point of care. Clin Chem 2001 47 1845 7. 

Mielsch, C., Zimmermann, A., Wagner, D., Matthes, B., Schlebusch, H., Luppa, P.B., 2010. Point-of-care determination of neonatal bilirubin with tbe blood gas analyzer RapidLab 1265. Clin. Cbem. Lab. Med. 48, 1455-1461. bttp //dx.doi.org/10.1515/ CCLM.2010.279. 

Conversely, the role of perfluorocarbons for oxygen transport and in vivo delivery is investigated. In addition to possible use as temporary blood substitute, these fluorocarbon molecules can be applied as respiratory gas carriers, for instance as lung surfactant replacement compositions for neonates and possibly for the treatment of acute respiratory distress syndrome for adults. Another... 

Whole blood is the most likely specimen for a clinical laboratory to receive for gas analysis and may be obtained from any site accessible to vascular catheterization or entry. These sites commonly are the vessels of the extremities, but special studies may require access to the chambers of the heart and great vessels of the chest. Analysts should recognize that some specimens are difficult to obtain and should be handled with utmost care. Sometimes the volume of the specimen collected for analysis, particularly from premature neonates, has to be as small as possible without sacrificing specimen quality and analytical accuracy. 

The ECG electrode is deposited as a microporous gas-permeable gold layer, which can be easily penetrated by the blood gases or tissue gases. Figure 23-6 shows the application of this combisensor to a neonate. 

The value of the partial pressure measured at the skin surface depends in a complex way on blood partial pressure, constitution of the skin, local perfusion, metabolism in the associated tissue, cardiac output, and application temperature. An increased temperature of 43 °C raises the gas permeability and expands the capillary vessels of skin which are filled with more artial blood. The local hyperemia has the disadvantage of limiting the application time at a certain site. Assuming stable circulation conditions, transcutaneously measured values correlate with arterial partial pressure by a factor of 1.2 (neonates) to 1.0 (small children) [1]. The measured value for adults proved to be very unreliable. In the case of unstable conditions or shock with a reduction of peripheral blood flow, the transcutaneous value drops very early. Inconvenience in routine use is caused by long preparation times of the sensor, the need for periodic membrane changes, the long run-in time of freshly prepared sensors, the necessity for periodic calibrations and the slow response time to changes in partial pressure. 

MLcromethod of Blood Diazepam Determination by Gas-Liquid Chromatography. Application in Neonatal Pharmacology... 

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