Blood coagulation thrombomodulin

Esmon CT The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989 264 4743-4761. 

Gailani D, Lasky NM, Broze GJ (1997) A murine model of factor XI deficiency. Blood Coagul Fibrinolysis 8 134-144 Healy AM, Rayburn HB, Rosenberg RD, Weiler H (1995) Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci USA 92 850-854... 

Healy AM, Hancock WW, Christie PD et al. (1998) Intravascular coagulation activation in a murine model of thrombomodulin deficiency effects of lesion size, age, and hypoxia on fibrin deposition. Blood 92 4188-4197 Weiler-Guettler H, Christie PD, Beeler DL et al. (1998) A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest 101 1983-1991... 

The fluid nature of blood can be attributed to the t1at cells (endothelial) that maintain a nonthrombogenie environment in the blood vessels. This is a result of at least four phenomena (a) the maintenance of a transmural negative electric charge that prevents adhesion between platelets (h) the release of a plasmalogen activator, which activates the fibrinolytic pathway (c) the release of thrombomodulin, a cofactor that activates protein C. a coagulation factor inhibitor and (d) the release of PGU. a potent inhibitor of platelet aggregation. 

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