Blood-cerebrospinal fluid barrier BCSFB

In addition, the epithelial cells of the choroid plexus facing the cerebrospinal fluid (CSF) constitute the blood-cerebrospinal fluid barrier (BCSFB). The BCSFB is also a significant area for exchange between the blood and the CSF. In rats the total calculated surface area of the choroid plexus is about 33% of that of the BBB [2]. In humans, based on the relative mass of the choroid plexus in comparison with the brain, the relative surface area of the choroid plexus may be in the region of 10% of that of the BBB. The CSF is secreted across the choroid plexus epithelial cells into the brain ventricular system [3] the remainder of the brain extracellular fluid (ECF) and the interstitial fluid (ISF) are secreted at the capillaries of the BBB themselves [4]. The ratio of fluid production from these sites is 40% 60%, respectively [5],... 

There are two barrier systems in the normal adult brain the blood-brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB). The BBB is composed of three cell types, all of which play an important role in BBB integrity and regulation endothelial cells of the cerebral vasculature, astrocytes, and pericytes (Fig. 1). Pericytes of BBB localize to the capillary basement membrane, sandwiched next to endothelial vessel cells by astrocytic end feet, which form very extensive and intimate bundles around both pericytes and endothelial vessel cells (Fig. 1). Specific characteristics of the BBB are believed to be maintained and induced by the astrocytic processes [28 30]. The endothelial cells of the cerebral vasculature differ from their counterparts in peripheral systems in that they lack fenestrations [31 33], demonstrate little to no... 

AIDS acquired immunodeficiency syndrome BBB blood-brain barrier BCSFB blood-cerebrospinal fluid barrier CBF cerebral blood flow... 

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