Blood cell adhesion regulation

Regulating blood cell adhesion via surface modification of polyurethanes... 

Calcium ions are essential in a variety of physiological processes including blood clotting, release of neurotransmitter at the synapse, cell division, cell adhesion, secretion, bioluminescence, membrane permeability, muscle contraction, and bio-mineralization35,174 176. In most of these systems, the disposition and functions of membrane proteins are a key in transport and regulation of calcium. Thus in order to understand the functionality of calcium one should look at a membrane system where the biochemical interplay of calcium is known in detail. 

R10. Ridley, R. C., Xiao, H., Hata, H., Woodliff, J., Epstein, J., and Sanderson, R. D., Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen. Blood 81,161—11A (1993). 

The significance of exon shuffling to protein evolution, in particular in respect to the development of multicellularity, is signified by a short inventory of processes involving proteins created by modular assembly. Exon shuffling facilitates the construction of proteins involved in regulation of blood coagulation, fibrinolysis, and complement activation, plus most constituents of the extracellular matrix, cell adhesion proteins, and receptor proteins [10, 57]. 

VE)-cadherin and platelet endothelial cell adhesion molecule-1 (PECAM-1). VE-cadherin is an endothelial-specific Ca " -regulated protein that is linked to the cytoskeleton via catenins (Fig. 1). PECAM-1, also known as CD31, is a key participant in the migration of blood-borne cells across the BBB. Changes in the adherent junction proteins can lead to increased paracellular permeability (Abbruscato and Davis, 1999) and leukocyte trafficking in the CNS (Newman, 1994 Garrido-Urbani et al., 2008). 

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