Block Copolymers for Multifunctional Self-assembled Systems

Assignee Ecole Polytechnique Federale de Lausanne (Lausanne, CH) [Pg.76]

A block copolymer effective as a controlled release agents of biologically active materials have been prepared. This agent consisted of ethylene oxide-propylene sulfide-ethylene oxide teipolymer that had been end-capped with a selected cysteine-containing peptide. These materials resist degradation prior to reaching their intended targets because they behave as multilamellar vesicles. [Pg.76]

Methoxypoly(ethylene glycol) (7 x 10 mol) was dissolved in 30 ml of CH2CI2 and then treated with triethylamine (0.016 mol) and p-toluene sulfonyl chloride (0.0135 mol). The mixture was stirred for 24 hours at ambient temperature. The mixture was then filtered to remove precipitated triethylammonium hydrochloride, concentrated, and the product was isolated after precipitation in cold diethyl ether. [Pg.77]

Preparation of Methoxy-Poly[Ethylene Glycol-b-Propylene Sulfide-b-(Ethylene Glycol) Monoacrylate)] [Pg.77]

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