Block Calypso Reaction

Charybdis Technologies. In the Calypso Reaction Block , multi-well reaetion arrays are designed for both solution and solid-phase synthesis applications. Well volumes range from 2 to 10 mL, pressures up to 207 kPa (30 psi), and temperatures from —80 to +180°C. 

Typical Experimental Procedure (Plate Production). Production of an 80-member array was successfully completed using a Charybdis 96-well Teflon block, encapsulated in a Calypso reaction frame assembly. Reagents were transferred into the 96-well plate using either a Quadra 96 or Rapid Plate 96. The blocks were then heated at 65° for 3 days and the solvent evaporated in vacuo at 65°. Scavenging with PS-TsNHNH2 (6 equiv.) and PS-NCO (1 equiv.) was performed at the plate level and the resins were added using a Millipore column loader. Evaporation was performed in a Savant evaporator for 2 h. 

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