Bleep

Alex, A., and Thornton, J.M. BLEEP -A potential of mean force describing protein-ligand interactions I. 

Mitchell, J. B. O., Laskowski, R. A., Alex, A., and Thornton, J. M. (1999) BLEEP-potential of mean force describing protein-ligand interactions I. Generating potential.. /. Comp. Chem. 20, 1165-1176. 

A hospital s bed manager is at the focal point of its operations. All requests for admission are made through the bed manager who is contacted via the bleep system. 

In the end I summarized the number of admission requests I had had to deal with from my daily paperwork, and counted the number of times I was bleeped, which varied between nineteen and seventy times a day. But my sketchy activity analysis did highlight the proportion of my time spent on ancillary, non-professional duties, which could perhaps be delegated, reduced or done differently. 

Argued the case for trialling a daily one-hour bleep-free period, as the medical staff already had, to allow time free of interruptions for work-related projects... 

A rapid bleeping tried hard to incite panic. Angel searched the map for changes. There metallic shells, buried beneath the snows, Miniature heat-sources flared and many of them started moving. 

First birds, first light. The alarm clock bleeped. Holmes knocked over a glass reaching for it, cold chamomile tea splashed the bed. He was up and in the shower. 

BLEEP—Potential of Mean Force Describing Protein—Ligand Interactions. I. Generating Potential. 

Chem., 20, 1177 (1999). BLEEP-Potential of Mean Force Describing Protein-Ligand Interactions. II. Calculation of Binding Energies and Comparison with Experimental Data. 

J. B. O. Mitchell, R. A. Laskowski, A. Alex, M. J. Forster and J. M. Thornton, BLEEP-Potential of mean force describing protein-ligand interactions II. Calculation of binding energies and comparison with experimental data.. Journal of Computational Chemistry, 1999, 20, 1177-1185. 

Mitchell and coworkers choose a different type of reference state for their BLEEP potential (315). The pair interaction energy is written as... 

Besides differences in the functional form and reference state, from a more practical point of view, the knowledge-based potentials differ also with respect to scope of atom type definitions and the amount of structural data used for their derivation. The number of different atom types ranges from 17 in Drug-Score to 40 nonmetal atom types in BLEEP. In all cases, the Protein Data Bank (321) was the source of the solved crystal structures. For BEEEP 351 selected complexes were used, whereas the PMF function was extracted from 697 complexes, and DrugScore was derived using 1376 complexes. In the latter case, the data have been extracted from Relibase (322,323). 

Soon after it was introduced, the Commodore 64 proved to be the leader of a new wave of home computers. Even at the original price of 600, the 64 came equipped with as much memory as 2,000 business machines, along with arcade-quality graphics, detailed animated sprites, and a unique sound synthesizer that brought realism to what was formerly just bleeps and tones. The 64 became one of the most popular computers ever, selling over 2,000,000 units worldwide. 

Mitchell et al. developed an atomic-level potential of mean force for protein-ligand interactions (BLEEP) based on two hydrogen types, 38 nonmetal heavy atom types, and 18 metal types [54]. The mean-force potential between atom types i and / at interatomic distance r was also derived based on Sippl s sparse data correction method [39]... 

Mitchell JBO, Laskowski RA, Alex A, Thornton JM. BLEEP-potential of mean force... 

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