Bladder paralysis

Mitoxantrone must not be given by intrathecal injection. Neuropathy and neurotoxicity have been reported. These reports have included seizures leading to coma and severe neurologic sequelae, and paralysis with bowel and bladder dysfunction. 

Cerebrum and cerebellum Motor nerve tracts Sensory nerve tract Balance problems, speech problems, coordination, tremors Muscle weakness, spasticity paralysis, vision problems, bladder, bowel problems Altered sensation, numbness, prickling, burning sensation... 

The major therapeutic uses of the cholinomimetics are for diseases of the eye (glaucoma, accommodative esotropia), the gastrointestinal and urinary tracts (postoperative atony, neurogenic bladder), the neuromuscular junction (myasthenia gravis, curare-induced neuromuscular paralysis), and very rarely, the heart (certain atrial arrhythmias). Cholinesterase inhibitors are occasionally used in the treatment of atropine overdosage. Several newer cholinesterase inhibitors are being used to treat patients with Alzheimer s disease. 

During spinal anesthesia, motor paralysis may impair respiratory activity, and residual autonomic nerve blockade can lead to hypotension upon ambulation. Residual autonomic blockade also interferes with bladder function, resulting in urinary retention and the need for bladder catheterization. 

The peritoneo-intestinal reflex is very much like the intestino-intestinal reflex, except that it results from irritation of the peritoneum it causes intestinal paralysis. The reno-intestinal and vesico-intestinal reflexes inhibit intestinal activity as a result of kidney or bladder irritation. Finally, the somato-intestinal reflex causes intestinal inhibition when the skin over the abdomen is irritatingly stimulated (Guyton, 1981). 

Other reports have noted symptoms of numbness and weakness in the hands and legs, ataxia (the loss of ability to coordinate muscle movement), impotence, paralysis of the bladder and bowel function, personality changes, and impaired memory and intellect. 

Amonronx, J., Gnillevin, L. Bladder neuropathy and gastric paralysis... 

Sodium chloride solution has been advocated in hyperkalemia, in order to avoid the potassium-containing polyionic fluids (Table 17.4). However this does not apply to the horse in the absence of clinical signs of hyperkalemia and with the exception of horses with hyperkalemic periodic paralysis or with a ruptured bladder, the hyperkalemia is likely to reflect acidosis and polyionic fluids are probably appropriate. 

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