Bis phosphoryl

IGF-I) receptor IGF-I receptor Partially active catalytic domain bis-Phosphorylated catalytic Activation loop Tyr1135 disordered... 

In contrast, synthesis of 3,4-diphosphorylthiophenes requires more elaboration because of low reactivity of 3,4-positions of thiophene and unavailability of 3,4-dihalo or dimetallated thiophenes. Minami et al. synthesized 3,4-diphosphoryl thiophenes 16 as shown in Scheme 24 [46], Bis(phosphoryl)butadiene 17 was synthesized from 2-butyne-l,4-diol. Double addition of sodium sulfide to 17 gave tetrahydrothiophene 18. Oxidation of 18 to the corresponding sulfoxide 19 followed by dehydration gave dihydrothiophene 20. Final oxidation of 20 afforded 3,4-diphosphorylthiophene 16. 3,4-Diphosphorylthiophene derivative 21 was also synthesized by Pd catalyzed phosphorylation of 2,5-disubstituted-3,4-dihalothiophene and converted to diphosphine ligand for Rh catalysts for asymmetric hydrogenation (Scheme 25) [47],... 

The TLR4-MD2 hetero-dimer has complex ligand specificity. It can be activated by structurally diverse LPS molecules, and minor changes in synthetic derivatives of LPS can abolish their endotoxic potency (Raetz and Whitfield, 2002 Rietschel et al., 1994). The diversity in potency of LPS is derived from variance within lipid A, as observed in both the number and the length of fatty acid side chains and the presence of terminal phosphate residues with a variety of modifications. Optimal lipid A potency is achieved with bi-phosphorylated, hexa-acylated, lipid A species (Raetz and Whitfield, 2002). Lipid A moieties that deviate from this pattern often demonstrate a significant decrease in endotoxic activity (Alexander and Rietschel, 2001). 

Giinstiger fiirUmamidierungen als l,3-Bis-[phosphoryl]-imidazol [s. Bd. XII/2 (4. Aufl.), S. 382] ist Phosphorsaure-N-methyl-imidazolid, das als Barium-Salz eingesetzt wird51-53. Die Umsetzungen mit Aminen werden in Wasser bei 20-60° (0,5-24 Stdn.) durchgefiihrt. Bei Zugabe von Ethanol kristallisieren die Bariumsalze der Phosphorsaure-monoamide (50-95%) aus. 

Ptdlns is the most abundant phosphatidylinositide in cells it constitutes about 90% of the inositol lipids in cell membranes. The other six mono- and bis-phosphorylated Ptdlns make up the remaining 10% with PtdIns(4)Pj and PtdIns(4,5)P2 constituting up about 9% of the lipid pool, each contributing different amounts depending on the tissue. The remaining five lipids make up 1%. PtdIns(3)Pi or PtdIns(5)Pi contribute about 0.4%, and the 3-lipids jointly constitute about 0.1%. These numbers vary slightly from cell to cell (Stephens et al., 2000 Vanhaesebroek et al., 2001), however, it is clear that the quantitatively minor inositol lipids Ptd(4,5)P2 and the 3-phosphorylated lipids play critical roles in signal transduction (Stephens et al., 2000 Toker and Cantley, 1997 Vanhaesebroek et al., 2001). 

Alcoholysis of the phosphoryl chloride produces the bis(phosphoryl)amine ... 

This reaction is very much like PGA Mutase, requiring the bis phosphorylated intermediate to form and to regenerate the phosphorylated enzyme intermediate. Note that this reaction is easily reversible, though it favors G-6-P. 

The anions of general formula [R12(Q1)PNP(Q1)R12] (1), known under the generic name of dichalcogenoimidodiphosphinates (R1 = alkyl, aryl) and dichalcogenoimidodiphosphates (R alkoxy, aroxy), are versatile ligands, formally derived from the corresponding bis(phos-phinyl)- and bis(phosphoryl)imides, R12(Q1)PNHP(Q1)R12 (2) by deprotonation. 

Hydrolysis or alcoholysis of tV-silylated imidodiphosphoryl derivatives (said to be useful for the purification of bis(phosphoryl) amides 71... 

Rubidium, caesium, and mixed potassium/rubidium and rubidium/caesium salts were obtained by treating bis(phosphoryl)amides, (Ar0)2(0)PNHP(0)(0Ar)2, with the appropriate alkali metal carbonates or their mixtures. The caesium salts can also be obtained with caesium hydroxide.58-60... 

Bis-[phosphoryl]-3H-pyrazole reagieren in konzentrierter Schwefelsaure bei 20° oder beim Erhitzen in Toluol unter Abspaltung des Phosphoryl-Restes aus der 4-Position z. B.1181 ... 

The reactions of bis(phosphoryl) disulphides with a variety of tervalent phosphorus acid derivatives or triphenylphosphine have been studied by means of low-temperature n.m.r. Intermediates were detected which indicated initial attack on one sulphur atom followed by substitution reactions at one of the phosphorus atoms, Arbuzov dealkylations, or phosphorane formation. An example is shown for the reaction of tributyl phosphite with bis(diethoxyphosphoryl) disulphide (25). In order to obtain solely thiophosphate products it is necessary to use bis(thiophosphoryl) disulphides, and one such compound (26) has been proposed as a highly effective reagent for the oxidation of oligonucleoside phosphites to phosphorothioates. A comparison of the efficiency of (26) with that of four other sulphurizing agents for use in... 

The final section of this Section of the Report is associated with the derivatives of trifluoromethyl hydroperoxide. The new compounds CF3OOPOF2 and CF3OPOF2 have been prepared by the reaction of trifluoromethyl hydroperoxide CF3OOH with iU-oxo-bis(phosphoryl difluoride), P2O3F4, and difluorophosphine-iw-oxo-phosphoryl difluoride, P2O4F4. The i.r. and n.m.r. spectra, physical properties, and some chemical reactions are reported for the new compounds. New synthetic routes to bis(trifluoro-methyl)bis(peroxy)carbonate (CF300>2C0 and trifluoromethyl fluoroformyl peroxide CF300C(0)F, based on the catalytic disproportionation of bis-(fluoroformyl) peroxide FC(0)00C(0)F, have also been derived. ... 

In another example, dibromo-(phenylearbazolyl)-phenylfluorene was eon-verted to the eorresponding bis(phosphoryl) compound via metallation with buthyl lithium followed by P-functionalization and oxidation (Scheme 8). ... 

Hydrazinium di-chlorophosphazene, Cl3P=N-N=PCl3, can be made by the Kirsanov reaction (7.498). It is a colourless very hygroscopic solid which is slightly soluble in POCI3, but insoluble in other common solvents. Controlled hydrolysis at low temperature leads to unstable hydrazido-N,N-bis(phosphoryl dichloride) (7.499), but with excess water the products are HCl, H3PO4 and N2H4 (7.500). 

Previously, it has been found that when using reagents 1-3 and 1,2-dichlorobenzene as a solvent the permeability values are as follows 17.4, 6.6, and 5.7 m s for ions Nd I and 13.5, 9.9, and 3.6 m s for Sc ". According to the results of the present research when using kerosene, the permeability values are lower 2.8,5.6, and 5.3 m s for ions Nd " and 3.6, 0.7, and 4.1 m s for Sc". We think that it can tell about contribution decrease of phosphoryl groups in diphosphorilamines in complex formation processes with the result that difference in values and P for mono-2.3 and bis-phosphorylated 1,4 amines is small. 

Pd-catalyzed reaction was reported to proceed via the dehydrogenative cis double phosphorylation and led to the formation of (Z)-bis-phosphoryl alkenes (Scheme 8.11) [74]. High product yield was obtained in the presence of additional equivalent of olefin for hydrogen absorption. 

Fukazawa A, Hara M, Okamoto T, Son EC, Xu C, Tamao K, Yamaguchi S (2008) Bis-phosphoryl-bridged stilbenes synthesized by an intramolecular cascade cyclization. Org... 

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